Inositol 1,4,5-trisphosphate is a second messenger generated by stimulation of the phosphoinositide cycle, thought to release calcium from intracellular stores. We have mapped the distribution of 3H-inositol 1,4,5-trisphosphate receptor binding sites in rat brain by autoradiographic techniques. The cerebellum contains the highest level of inositol 1,4,5-trisphosphate binding sites in brain, whi...

Unilateral ablation of cerebral cortical areas 4 and 6 of Brodmann in the macaque monkey results in a dense contralateral hemiplegia that recovers partially with time. During the phase of dense hemiplegia, the local cerebral metabolic rate for glucose (lCMRGlc) is decreased significantly in the caudate nucleus, putamen, globus pallidus, subthalamic nucleus, substantia nigra, and red nucleus of ...

background: oleuropein is a phenolic compound which is present in the olive leaf extract. the purpose of the present study was to investigate the neuroprotective effect of oleuropein as an antioxidant agent on the substantia nigra in aged rats. methods: twenty 18-month-old wistar rats (450-550 g) were randomly divided into control and experimental groups. the experimental group received a daily...

OBJECTIVE To determine whether a positive L-dopa response in vascular parkinsonism (VP) is correlated with the presence of nigrostriatal pathology due to either vascular damage or neuronal cell loss. METHODS Seventeen patients with pathologically confirmed VP were selected from the pathological collection of the Queen Square Brain Bank for Neurological Disorders, and their L-dopa response dur...

Ferritin is a 12 nanometer (nm) diameter iron storage protein complex that found in most plants and animals. A substantial body of evidence has established electrons can tunnel through between ferritin nanoparticles it exhibits Coulomb blockade behavior, which also seen quantum dots nanoparticles. This be used to understand the behavior these particles for use nanoelectronic devices, biomedical...

OBJECTIVE Our objective is to determine the value of enhanced substantia nigra echo in the diagnosis of Parkinson's disease by analyzing the intensity and area of substantia nigra echo by transcranial Doppler sonography (TCS). PATIENTS AND METHODS 36 patients diagnosed as ultra early stage Parkinson's disease between 2013 November and 2014 August were selected as the disease group, and 32 hea...

in order to study the qualitative, quantitative characteristics of a pure common populus alba stand in polkalleh & a mixed stand of populus alba & populus nigra in karchegan, two 30-year-old stands were selected with a plantation interval ( spacing) of 2.5 × 1.5 m in each of which 30 pcs of 2 are samples were randomly selected. in each sample pc all the trees diameters were measured using a dia...