The present study was aimed to study the acute and subacute toxicity studies with orally administered 50% ethanolic leaves extract of Ocimum sanctum Linn (OSE). In acute toxicity tests, four groups of mice (n = 6/group/sex) were orally treated with doses of 200, 600, and 2000 mg/kg, and general behavior, adverse effects, and mortality were recorded for up to 14 days. In subacute toxicity study,...

In order to investigate the toxicity of rutin-rich dough from the Tartary buckwheat variety 'Manten-Kirari,' acute and subacute toxicity studies (10,000 and 5,000 mg/kg flour, respectively) were performed using rats. In the acute toxicity study, no toxic symptoms were observed and no rats died during the test. Body weight in the 'Manten-Kirari'-treated group was not significantly different when...

The aim of the current study was to evaluate Morinda citrifolia (noni) seed extract, a food ingredient, for potential toxicity and antioxidant activity. Nitrates, nitrites, phytic acid, oxalic acid, as well as aflatoxins B1, B2, G1 and G2 were not detected in the extract. The extract was also non-cytoxic (LC50 > 1 mg/mL) in the 24 and 40 h brine shrimp toxicity test. There were no symptoms of t...

Article history: Received on: 21/10/2016 Accepted on: 24/01/2017 Available online: 30/05/2017 The present study was carried out to evaluate the safety of Asparagus racemosus root ethanol extract, isoprinosine and shatvari syrup by acute ad subacute toxicity studies. Acute and subacute oral toxicity study was conducted according to the guidelines of OECD 425 and 407 respectively. In acute oral t...

Senna alata has attracted the attention of many researchers due to its numerous medicinal properties. This study aims to test the acute and sub-acute toxicity of its leaf extracts in Swiss albino mice. Studies were carried out with a fixed dose of 1,000, 2,000, and 3,000 mg/kg body weight through oral administration daily. Signs of toxicity in terms of behavior and mortality were noted after ev...

Ginseng (Panax ginseng) and Ashwagandha (Withania somnifera) are widely used as geriatric tonics. Both individually have not shown any toxicity on long term administration. Study was planned to assess the safety of the combination by doing subacute toxicity study in rats with 90 days oral administration using three doses. Food consumption, body weight, haematological, biochemical and histopatho...

The aim of the study was to determine the effects of taurine in rats exposed to subacute dichlorvos toxicity. Fifty rats were weighed and assigned into five groups of ten rats each. The groups received: distilled water, soya oil (1 ml/kg), taurine (50 mg/kg), dichlorvos (10 mg/kg) and the combination treatment group received taurine first and then dichlorvos 30 min later. The treatments were ad...