stachys lavandulifolia ( s. lavandulifolia ) is a plant that has been widely used as an herbal medicine in iran. unfortunately, despite the prevalent medicinal uses of the plant, there are no reports on the possible toxic effects of s. lavandulifolia . in the present study the potential toxicity of s. lavandulifolia after acute and sub-chronic administration in rats was evaluated. rats were ora...

prohibitins are chaperone proteins highly conserved among eukaryotes. many different functions have been attributed to prohibitins depending on their tissue expression and sub-cellular localization. prohibitins play a major role in mitochondrial physiology, regulating the stability and the processing of both respiratory chain complex subunits and opa1, a mitochondrial fusion regulating protein....

The extracts of Anacardium occidentale have been used in the management of different cardiovascular disorders in Nigeria. These have necessitated the assessment of the toxicity of this plant extract in sub-chronic administration. The inner stem bark of Anacardium occidentale was extracted with 80 % methanol and quantitatively analysed for antinutrients and some heavy metals. The phytochemical c...

Saffron (Crocus sativus L.) has been considered as a medicinal plant since ancient times and also widely used as food additive for its color, taste and odor. The pharmacological properties of saffron and its main constituents, crocin and safranal have been evaluated using different in vivo and in vitro models. Additionally, other lines of studies have found toxicological effects of saffron.  Ho...

INTRODUCTION Clerodendrum capitatum (Willd) Schumach. & Thonn (Lamiaceae) is used in African traditional medicine for the treatment of malaria, hypertension, obesity, jaundice and diabetes however there is lack of experimental data on its possible toxicity. This study investigated the acute and 28 days sub-chronic toxicity of C. capitatum in Wistar rats. METHODS In acute toxicity tests, a sin...

Thallium (Tl) is one of the most toxic heavy metals affecting both humans and animals, yet least studied for its toxicological effects. A total 40 male Wistar rats were randomly divided into four Groups with 10 in each Group. Group I received distilled water only served as a control. II, III, IV thallium sulfate (I) at 0.48, 0.93, 1.33 mg/kg body weight, respectively, drinking 90 days. In rats,...

Silver salts and nanosilver (NS) are the common antimicrobial used in the treatment of chronic wounds, so they are important to assess their dermal toxicity. Therefore, in this study, the possible dermal toxicity of NS particles and silver nitrate (AgNO3), was tested by determining the serum level of transforming growth factor-β1(TGF-β1) and study on of mouse skin tissue. In this stu...