Subacute sclerosing panencephalitis is a chronic and fatal disease of the central nervous system. Most patients present with progressive psychointellectual disturbances. A 14-month-old girl was admitted to our hospital because of left-sided hemiparesis. During hospitalization, focal and generalized seizures occurred. The electroencephalogram (EEG) revealed that periodic lateralized discharges c...

Abbreviations: MMR: Measles, Mumps and Rubella; WHO: World Health Organization; SSPE: Subacute Sclerosing Panencephalitis; PAHO: Pan American Health Organization; CRS: Congenital Rubella Syndrome; MR: Measles-Rubella; GSK: GlaxoSmithKline; EZ: Edmonston Zagreb; CEF: Chicken Embryo Fibroblast; IBD: Inflammatory Bowel Disease; CDC: Centers for Disease Control and Prevention; SSPE: Subacute Sclero...

The MR findings in three patients with subacute sclerosing panencephalitis were reviewed and compared with CT findings in the same patients. Long-T2 lesions were demonstrated in each case, although their distribution varied with the clinical stage of the disease. MR, especially T2-weighted imaging, appears to be of great utility in the assessment of subacute sclerosing panencephalitis.

We describe the clinical presentation and clinical course of subacute sclerosing panencephalitis in a 13-year-old previously healthy boy who recently immigrated to the United States from Iraq. He presented with macular retinopathy, followed by progressive myoclonus and encephalopathy. After extensive workup, a diagnosis of subacute sclerosing panencephalitis was suspected by the presence of per...

Subacute sclerosing panencephalitis is a neurodegenerative disease secondary to measles infection that usually has a typical presentation with progressive myoclonia, cognitive decline, and periodic slow-wave complexes on electroencephalography. We report two pediatric cases who presented with periodic myoclonic jerks and cognitive decline. In both cases, the electroencephalogram showed continuo...

Cellular and humoral immunity was studied in 26 patients with subacute sclerosing panencephalitis. Results were compared with those of 14 normal controls and 11 patients suffering from other neurological disorders. It was shown that cellular and humoral immune responses are adequate in subacute sclerosing panencephalitis. The persistently elevated levels of serum immunoglobulin G (IgG) and IgA ...

An appendix removed 15 days before onset of symptoms of subacute sclerosing panencephalitis was examined retrospectively for measles virus ribonucleic acid (RNA). Tissue sections hybridised in situ to a cloned measles virus probe of deoxyribonucleic acid specific for nucleocapsid protein showed that many cells of the lymphoid tissue contained measles virus RNA. In contrast, only a few infected ...

A difficult case 289 Hypoactive–hypoalert behaviour and thalamic hypometabolism due to intracranial hypotension S Kearney, P Flynn, S Hughes, W Spence, M O McCarron 293 Chorioretinitis: a potential clue to the early diagnosis of subacute sclerosing panencephalitis V Jeevagan, A Dissanayake 297 Acute segmental poliomyelitis-like flaccid paralysis in an adult in the UK, associated with enteroviru...