Altered receptive fields and sensory modalities of rat VPL thalamic neurons during spinal strychnine-induced allodynia. J. Neurophysiol. 78: 2296-2308, 1997. Allodynia is an unpleasant sequela of neural injury or neuropathy that is characterized by the inappropriate perception of light tactile stimuli as pain. This condition may be modeled experimentally in animals by the intrathecal (i.t.) adm...

in this study, phytotoxicity of allelochemical barley (hordeum vulgare) extracts on chenopodiom album germination and enzymes activities were bioassay. allelopathic extracts were a phenolic and three alkaloids compounds (strychnine, atropine and quinine). experiment was carried out under completely randomized design with three replications. results indicated that the alkaloids atropine and stry...

Three subspecies of the California ground squirrel (Spermophilus beecheyi) were studied. In the first test of Experiment 1, Beechey (S. b. beecheyi), Douglas (S. b. douglasii), and, for comparative purposes, Sierra (S. b. sierrae) ground squirrels were each offered a drinking tube containing one of three H20 solutions of strychnine sulfate (0.01, 0.05, or 0.5%) after being deprived of water for...

Strychnine, a potent and selective antagonist at glycine receptors, was found to inhibit muscle (alpha1beta1gammadelta, alpha1beta1gamma, and alpha1beta1delta) and neuronal (alpha2beta2 and alpha2beta4) nicotinic acetylcholine receptors (AcChoRs) expressed in Xenopus oocytes. Strychnine alone (up to 500 microM) did not elicit membrane currents in oocytes expressing AcChoRs, but, when applied be...

Strychnine is a potent, naturally occurring neurotoxin that effectively protects plants from animal pests by deterring feeding behavior. In insects, such as the fruit fly, Drosophila melanogaster, bitter-tasting aversive compounds are detected primarily through a family of gustatory receptors (GRs), which are expressed in gustatory receptor neurons. We previously described multiple GRs that eli...

High-affinity binding sites for the convulsant alkaloid strychnine appear t o reside on a 48 kDa subunit of receptors for the inhibitory neurotransmitter glycine in the mammalian spinal cord [ I , 21. During a series of experiments to investigate the role of different amino acid residues in the recognition of strychnine at the glycine receptor, we found that modification o f arginine residues w...

Cys-loop receptors (CLR) are pentameric ligand-gated ion channels that mediate fast excitatory or inhibitory transmission in the nervous system. Strychnine and d-tubocurarine (d-TC) are neurotoxins that have been highly instrumental in decades of research on glycine receptors (GlyR) and nicotinic acetylcholine receptors (nAChR), respectively. In this study we addressed the question how the mole...

Four adult female Botta's pocket gophers (Thomomys bottae) that had survived many normally potentially lethal doses of strychnine alkaloid in another experiment (Lee 1986) were examined further. These individuals freely consumed 0.5% strychnine bait, and 3 of them also 1% strychnine bait, for long periods without dying, whether or not nontoxic alternate bait was present. After 1 gopher (#5) was...

The inhibitory glycine receptor, a ligand-gated ion channel that mediates fast synaptic inhibition in mammalian spinal cord and brainstem, is potently and selectively inhibited by the alkaloid strychnine. The anthelminthic and anticonvulsant ivermectin is a strychnine-independent agonist of spinal glycine receptors. Here we show that ivermectin is an effective antidote of strychnine toxicity in...