نتایج جستجو برای: structural dependent biological activity
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Neuronal activity regulates the transcription of a large set of genes, many of which encode proteins that modify synaptic function. In this issue of Neuron, Hong et al. selectively impair activity-dependent Bdnf transcription and demonstrate that this process is required for inhibitory synapse development.
Objective(s): The structure- activity relationship of a series of 36 molecules, showing L-type calcium channel blocking was studied using a QSAR (quantitative structure–activity relationship) method. Materials and Methods: Structures were optimized by the semi-empirical AM1 quantum-chemical method which was also used to find structure-calcium channel blocking activity trends. Several types of ...
Attempts to control cancer involve a variety of means, including the use of suppressing, blocking and transforming agents. Suppressing agents prevent the formation of new cancers from pro-carcinogens, blocking agents prevent carcinogenic compounds from reaching critical initiation sites, while transformation agents act to facilitate the metabolism of carcinogenic components into less toxic mate...
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