نتایج جستجو برای: stress degradation
تعداد نتایج: 580978 فیلتر نتایج به سال:
In this letter, the characteristics of positive bias temperature instability (PBTI) and hot carrier stress (HCS) for the lowtemperature poly-Si thin-film transistors (LTPS-TFTs) with HfO2 gate dielectric are well investigated for the first time. Under room temperature stress condition, the PBTI shows a more serious degradation than does HCS, indicating that the gate bias stress would dominate t...
Heat shock protein (Hsp)70 is a molecular chaperone that maintains protein homoeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. However, the mechanisms by which Hsp70 balances these opposing functions under stress conditions remain unknown. Here, we demonstrate that Hsp70 preferentially facilitates protein refolding after stress, gradually swit...
We previously reported that shear stress induces phosphorylation and disassembly of keratin intermediate filaments (IFs). Shear stress also induces a time- and strain-dependent degradation of keratin IFs, and the current study examines the mechanisms involved in degradation of keratin proteins in human A549 cells exposed to 0-24 h of shear stress (7.5-30 dynes/cm(2)). Ubiquitin was found to be ...
Juvenile hormone (JH) degradation was studied under normal and stress conditions in young and matured females of Drosophila melanogaster strains having mutations in different genes involved in responses to stress It was shown that (1) the impairment in heat shock response elicits an alteration in stress-reactivity of the JH system; (2) the impairment JH reception causes a decrease of JH-hydroly...
A fixed-dose combination of atorvastatin and aspirin is widely used for the treatment of myocardial infarction. The present work describes a comprehensive study of the stress degradation behavior of atorvastatin and aspirin alone as well as in combination of 1:1 and 1:7.5 ratios, respectively, as per ICH guidelines. The degradation products of aspirin as well as atorvastatin were successfully s...
1. Introduction Continued shrinking of RF MOSFET gate length leads to thinner silicon oxide film and higher electrical field and thus can results in reliability issues [1]. Previous works to evaluate the RF circuit degradation mainly focused on hot carrier instability (HCI). HCI stress will induce interface states and oxide traps near the drain junction and thus causes the degradation of f t an...
The nucleolar protein PICT1 regulates tumor suppressor p53 by tethering ribosomal protein L11 within the nucleolus to repress the binding of L11 to the E3 ligase MDM2. PICT1 depletion results in the release of L11 to the nucleoplasm to inhibit MDM2, leading to p53 activation. Here, we demonstrate that nucleolar stress induces proteasome-mediated degradation of PICT1 in a ubiquitin-independent m...
The objective of current study was to develop a validated specific stability indicating reversed-phase liquid chromatographic method for the quantitative determination of desvenlafaxine in bulk sample and pharmaceutical dosage form in the presence of degradation products. Forced degradation studies were performed on bulk sample of desvenlafaxine as per ICH prescribed stress conditions using aci...
Abstract: A step-stress test in the presence of competing risks and using degradation measurements is considered. It is assumed that underlying degradation path follows a concave degradation model and the intensity functions corresponding to competing risks depend only on the level of degradation. In this work, information from step-stress test at high level of stress is extrapolated, through a...
This work presents very recent results regarding threshold-voltage ( V T ) degradation due to the application of an AC gate-bias stress (also known as a gate-switching stress). We show that this phenomenon includes both seemingly-permanent shift and increase in observed hysteresis. effect is found primarily trench-geometry devices when exposed what can be described negative bias overstress exce...
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