Inbred strains of mice vary in their sensitivity to the diabetogenic effects of streptozotocin (STZ). To investigate the basis for this strain difference we exposed islet cells from two strains of mice that differ in sensitivity to the drug. We examined them morphologically and measured islet NAD + NADH content, streptozotocin metabolite accumulation, glucose transport capacity, Glut2 levels an...

Streptozotocin (STZ) (2-deoxy-2-({[methyl(nitroso)amino]carbonyl}amino)-β-D-glucopyranose) is a naturally occurring diabetogenic compound, produced by the soil bacterium streptomyces achromogenes, that exhibits broad spectrum of antibacterial properties. Streptozotocin functions as a DNA synthesis inhibitor in both bacterial and mammalian cells. In mammalian cells, the actual mechanism and meta...

Abstract Background Diabetes, a global cause of mortality in developing countries is chronic disorder affecting the metabolism macromolecules and has been attributed to defective production action insulin characterized by persistent hyperglycemic properties. This harms organs body such as liver, kidney spleen. Medicinal plants Hunteria umbellate have shown possess hypoglycemic, antioxidative an...

Objective: The high global incidence of type 2 diabetes has challenged researchers to establish animal models that resemble the chronic stage observed in type 2 diabetes patients. One such model is induced by neonatal streptozotocin (n-STZ) administration to rat pups at 0, 2, or 5 days after birth. In this study, we assessed Ins-1 gene expression and tissue insulin levels as well as serum conce...

angiotensin-converting enzyme (ace) inhibitors including quinapril could exert a protective effect on cardiovascular system through endothelial system in normoglycemic and diabetic rats. the present experimental work was designed to study the vascular reactivity of aortic ring segments isolated from streptozotocin (stz)-diabetic rats treated for 4 weeks with nitro-l-arginine-methyl ester (l-nam...

Diabetes is a life-threatening disease, and currently available synthetic medicines for treating diabetes are associated with various side effects. Therefore, there an unmet need to develop herbal remedies against as alternative medicines. Although local healers use the roots of Spermadicyton suaveolens (SS) manage diabetes, negligible research validate its antidiabetic properties. The present ...

The cytokines IFN-?, interleukin IL-1?, and TNF-? each up regulate the expression of major histocompatibility complex (MHC) are therefore considered as inflammatory markers. present study aimed to measure serum levels in mice after induction diabetes with streptozotocin correlate their lipid glycaemic profiles. included 40 Swiss Albino (20 males 20 females), half male female groups were made di...

Protein kinase C (PKC) is a promoter enzyme that plays vital role in signal transduction of vascular smooth muscle cells (VSMCs). It has numerous functions, such as cell growth, cytokine activation and angiogenesis. But, these mechanisms are deteriorating diabetes mellitus. Angiotensin II (Ang II) effects on structure binding Ang type-1 type-2 receptors (ATR1 ATR2) stimulates PKC mostly through...

Antidiabetic properties of fermented foods have been previously demonstrated. This study aimed to examine the antidiabetic and hypolipidemic potential activities L. plantarum oat extract in Streptozotocin-induced diabetic rats. Firstly, inoculating 1% starter culture 10% whole flour aqueous media resulted 8.36 log CFU mL?1 pH 4.60 after 72 h fermentation at 37 °C. With time progression fermenta...

The state of lipid peroxidation (LPO), respiration and oxidative phosphorylation, mitochondrial permeability transition pore (mPTP) antiradical activity rat liver mitochondria in streptozotocin (STZ)-induced diabetes condition were studied, considered the ways correction detected membrane damages with use gossitan, isolated from cotton plant Gossypium hirsutum L. It was shown that rate states V...