Lechevalier, Hubert A. (Rutgers, The State University, New Brunswick, N.J.), Mary P. Lechevalier, and Pauline E. Holbert. Electron microscopic observation of the sporangial structure of strains of Actinoplanaceae. J. Bacteriol. 92:1228-1235. 1966.-Eight strains of Streptosporangium spp. and one strain each of Spirillospora albida and an Ampullariella-like Actinoplanes sp. were observed by elect...

WS79089B a highly specific endothelin converting enzyme (ECE) inhibitor has been isolated from the fermentation broth of Streptosporangium roseum No. 79089. WS79089B showed highly selective ECE inhibition activity with IC50 value of 0.14 microM and behaved as a competitive inhibitor of ECE, with Ki values of 8.9 x 10(-8) M. The sodium salt of WS79089B (FR901533) inhibited big endothelin-1 (big ...

Farnesyl diphosphate (FPP) and all fifteen positional isomers of ((13)C1)FPP were enzymatically converted by the bacterial terpene cyclases corvol ether synthase from Kitasatospora setae, the epi-cubebol synthase from Streptosporangium roseum, and the isodauc-8-en-11-ol synthase from Streptomyces venezuelae. The enzyme products were analysed by GC-MS and GC-QTOF MS(2) and the obtained data were...

After growth of representatives of eight genera in the order Actinomycetales and two others related taxonomically to Mycobacterium under iron-deficient conditions, the following compounds were found in the media : salicylic and phenylacetic acids, but no mycobactin, with Thermoactinomyces vulgaris; 2,3dihydroxybenzoic acid with Corynebacterium equi, Mycococcus sp., Nocardia opaca and Streptospo...

Sibiromycin, possessing strong antitumor activity in animal experiments, is produced by Streptosporangium sibiricum. Sibiromycin can be isolated from culture filtrate using ion-exchange or by solvent extraction. The antibiotic was obtained as a crystalline substance with ultraviolet absorption maximaat 230 and 310 nm, [a]D+525° (in dimethylformamide); the empirical formula-C24H31N3O7. In 1 N hy...