Fibronectin-binding proteins (FnBPs) of Staphylococcus aureus and Streptococcus pyogenes mediate invasion of human endothelial and epithelial cells in a process likely to aid the persistence and/or dissemination of infection. In addition to binding sites for the N-terminal domain (NTD) of fibronectin (Fn), a number of streptococcal FnBPs also contain an upstream region (UR) that is closely asso...

Streptococcal bacteria are among dangerous human pathogens with major prevalence worldwide. A good vaccine against streptococcal bacteria should have epitopes that confer protection from infection by different streptococcal bacteria types. we aimed was to recognize the most immunogenic and conserved epitopes of streptococcal bacteria, which could be a potential candidate for vaccine development...

An elevated titer of anti-aorta antibodies was detected with a significantly higher frequency in cases of aortitis syndrome than in those of other diseases by the complement fixation test and tannic acid hemagglutination test. This finding indicates participation of immune mechanism in the development of aortitis syndrome. The direct fluorescent antibody technique disclosed that aorta antigens ...

Selection of new variants of the streptococcal inhibitor of complement protein has been implicated in the perpetuation of epidemics caused by serotype M1 strains of group A Streptococcus (GAS). The frequency at which new streptococcal inhibitor of complement (Sic) variants arise in an infected individual is not known. To study this issue, the sic gene was sequenced in 100 isolates cultured from...

Collagen I foams are used in the clinic as scaffolds to promote articular cartilage repair as they provide a bioactive environment for cells with chondrogenic potential. However, collagen I as a base material does not allow for precise control over bioactivity. Alternatively, recombinant bacterial collagens can be used as "blank slate" collagen molecules to offer a versatile platform for incorp...

sydenham’s chorea is a delayed complication of group aßhaemolytic streptococcal infections and forms one of the majorcriteria of acute rheumatic fever.it is characterised bychorea, muscular weakness, and a number of neuropsychiatricsymptoms. it is considered to be an autoantibody mediated disorderwith the evidence suggesting that patients with sydenham’schorea produce antibodies that cross reac...

Among the infective diseases of man in which allergy is thought to play an important part, rheumatic fever is outstanding. It is associated with a haemolytic streptococcal infection of 3 to 4 weeks' duration, high antitoxin levels, and marked sensitivity to streptococcal allergens. The tissues do not show the " pyogenic response" commonly associated with haemolytic streptococci, but a widesprea...