The   stembark of Mammea africana is used traditionally for the treatment of stomach pains. The present study was designed to evaluate the effects of ethanolic stembark extract of Mammea africana on experimentally induced diarrhoea and ulcer . The extract ( 30 – 90mg/kg) was administered orally in rats 30 minutes to one hour before the induction of diarrhoeal and ulcer using di...

Glycyrrhiza glabra L. is used in folk medicine for treatment of stomach disorders includingpeptic ulcers. The hydroalcoholic extract of Glycyrrhiza glabra L. (HEGG) was evaluated forantiulcerogenic activity and acute toxicity profile in mice. Various doses of HEGG (50-200mg/kg) were administered orally to animals of different groups. Omeprazole and cimetidine atdoses of 30 and 100 mg/kg were us...

BACKGROUND It is not known which region of the stomach is responsible for symptom generation or whether symptoms induced by gastric distension are region specific. Also, it is unclear whether low level gastric distension has a modulatory role on gastric tone and mechanosensitivity. AIMS To define differences in the sensorimotor response to distension between proximal and distal gastric disten...

Dopamine has an effective role on gastric acid secretion (GAS). The role of peripheral and central dopamine D1/DA1 receptors on stimulated GAS are unknown. The objective of the present study was to use SKF38393 and SCH23390 on stimulated GAS. For all gastric sampling, animals (Sprague Dawley rats) were anesthetized and a polyethylene tube was introduced into the stomach through esophagus and a ...

The effects of fourth ventricular administration of ghrelin on motility of the proximal stomach were examined in anesthetized rats. Intragastric pressure (IGP) was measured using a balloon situated in the proximal part of the stomach. Administration of ghrelin into the fourth ventricle induced relaxation of the proximal stomach in a dose-dependent manner. Significant reduction of IGP was observ...

h. pylori  is a human pathogen that colonizes the epithelium of the stomach. the host immune response may influence the disease process, where cytokines play important roles in the development of disease. in this study, the concentrations of selected cytokines in the gastric antrum and stomach body mucosa and also in the serum were evaluated. eighty patients according to their rapid urease test...

We investigated the regulatory mechanism of acid-induced HCO(3)(-) secretion in the slightly permeable rat stomach after an exposure to hyperosmolar NaCl. Under urethane anesthesia, a rat stomach was mounted on a chamber and perfused with saline, and the secretion of HCO(3)(-) was measured at pH 7.0 using a pH-stat method and by adding 2 mM HCl. Acidification of the normal stomach with 100 mM H...

Epstein-Barr virus (EBV)-encoded BamHI-A rightward frame 1 (BARF1) is a putative viral oncogene in EBV-infected stomach cancer. The aim of the present study was to investigate BARF1-induced cellular protein and microRNA alterations. In this study, BARF1-expressing stomach cancer cells showed a high rate of proliferation, high levels of NFκB, and miR-146a upregulation, which was reversed by NFκB...

Rat stomach cancers induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) are widely used as a model of differentiated-type human stomach cancers. ACI/N (ACT) rats are susceptible and BUF/Nac (BUF) rats are resistant to MNNG-induced stomach carcinogenesis, and the presence of an autosomal gene with a dominant BUF allele has been suggested. In this study, we performed a carcinogenicity test by ...

Cisapride strongly stimulates gastrointestinal motor activity simultaneously from stomach to jejunum in the interdigestive state. The contractile pattern in the stomach was quite similar to that of the natural interdigestive mingrating contractions (IMC) in all respects, frequency, contractile force, and coordination between the gastric body and antrum. However, the cisapride-induced IMC-like c...