introduction: this study was designed to investigate the effects of granulocyte colony-stimulating factor (g-csf) administration in rats for 6 weeks after traumatic brain injury (tbi). methods: adult male wistar rats (n = 30) were injured with controlled cortical impact device and divided into four groups. the treatment groups (n = 10 each) were injected subcutaneously with recombinant human g-...

background: there are many reports regarding to effects of granulocyte colony-stimulating factor (g-csf) and stem cell factor (scf)alone in liver repair .but conflicting data have been reported regarding the role of growth factors such as g-csf and scf in the liver regeneration system. also, there is not such data regarding to effects of co-administration both of g-csf and scf in the liver dama...

the cytokine of granulocyte macrophage colony stimulating factor (gm-csf) is a glycoprotein, which is synthesized in the female reproductive tract and has embryonic trophic effect in mammals. the objective of this study was to examine the optimal dosage of gm-csf to improve the mouse embryo development in vitro. to collect two and eight cells embryos, the pregnant nmri mice were sacrificed by c...

bakground: granulocyte colony-stimulating factor (g-csf) is a cytokine that stimulates hematopoiesis and induces proliferation and differentiation of granulocyte progenitor cells as well as production of bone marrow neutrophilic granulocyte colonies.  nowadays, human recombinant g-csf(hr g-csf) is used for the treatment of chemotherapy- and radiotherapy-induced neutropenia, and also in patients...

background: stroke is the third leading cause of death. hypothermia has been recognized as an effective method in reducing brain injury. in this study, we assessed the effects of granulocyte colony-stimulating factor (g-csf) as a neuroprotective agent and mild hypothermia on mortality, behavioral function, infarct volume, and brain edema in wistar rats. methods: forty male rats were used in fiv...

traumatic brain injury (tbi) is described as a situation in which the brain is damaged by an external force. it is considered to be a chief problem in health care. pharmacotherapy and stem cell therapy are the main treatments used in tbi. the purpose of these procedures is to control the inflammation in injured regions of brain. currently, there is no effective care for tbi that could regenerat...

BACKGROUND Biopharmaceutical drugs are mainly recombinant proteins produced by biotechnological tools. The patents of many biopharmaceuticals have expired, and biosimilars are thus currently being developed. Human granulocyte colony stimulating factor (hG-CSF) is a hematopoietic cytokine that acts on cells of the neutrophil lineage causing proliferation and differentiation of committed precurso...

BACKGROUND Human granulocyte colony-stimulating factor (hG-CSF) can serve as valuable biopharmaceutical for research and treatment of the human blood cancer. Transplastomic plants have been emerged as a new and high potential candidate for production of recombinant biopharmaceutical proteins in comparison with transgenic plants due to extremely high level expression, biosafety and many other ad...