Although in common use, there is still controversy as to the way in which gold and penicillamine act in rheumatoid arthritis (RA). In this study, synovial fluids from 4 groups of patients have been compared: (1) RA patients on gold/penicillamine, (2) RA patients on non-steriodal anti-inflammatory drugs (NSAID) only, (3) osteoarthritis patients, and (4) patients with sero-negative arthropathies....

arthritis refers to different medical conditions associated with disorder of the primary structures that determine joint functions such as bones, cartilage and synovial membranes. drug discovery and delivery to retard the degeneration of joint tissues are challenging. current treatments of different arthritis involves administration of ideal non-steroidal anti-inflammatory drugs (nsaids) but ar...

Cyclooxygenase-2 (COX-2) is a key molecule in the inflammatory pathway in amyotrophic lateral sclerosis (ALS). Cytosolic phospholipase A (cPLA2) is an important enzyme providing substrate for cyclooxygenases. We therefore examined cPLA2 expression in human ALS and mutant Cu/Zn superoxide dismutase (SOD1) transgenic mice and its relation to COX-2. Immunohistochemistry and real-time RT-PCR reveal...

/3-Adrenergic agonists have been used extensively and successfully in the treatment of reversible airways diseases such as asthma (Djurup, 1981). This form of therapy has proven to be particularly beneficial when the /3stimulant drug is targeted mechanically by aerosol administration directly to the defective tissue, namely the lung. Oral administration of the /3-agonist has proven less satisfa...

Danazol, a weekly androgenic, heterocyclic compound with anabolic properties, is used primarily in the treatment of endometriosis and other gynecological complains. Effects of co-administration of enalapril, angiotensin converting enzyme inhibitor (ACE inhibitor) with danazol on some of biochemical parameters in rats were studied. Treatment of rats with danazol (200mg/kg i.p) for 15 days induce...