SHED (stem cells from human exfoliated deciduous teeth) represent a population of postnatal stem cells capable of extensive proliferation and multipotential differentiation. Primary teeth may be an ideal source of postnatal stem cells to regenerate tooth structures and bone, and possibly to treat neural tissue injury or degenerative diseases. SHED are highly proliferative cells derived from an ...

OBJECTIVES Mesenchymal stem cells or "multipotent stromal cells" are heterogeneous cell population with self-renewal and multilinage differentiation. The aim of this study was to examine and compare the expression of important stem cell surface markers on two populations of mesenchymal stem cells, one derived from human exfoliated deciduous teeth and the other derived from human adipose tissue....

objective: the neural crest is a transient structure of early vertebrate embryos that generates neural crest cells (nccs). these cells can migrate throughout the body and produce a diverse array of mature tissue types. due to the ethical and technical problems surrounding the isolation of these early human embryo cells, researchers have focused on in vitro studies to produce nccs and increase t...

Stem cells from human exfoliated deciduous teeth (SHED) are isolated from the dental pulp tissue of primary teeth and can differentiate into neuronal cells. Although SHED are a desirable type of stem cells for transplantation therapy and for the study of neurological diseases, a large part of the neuronal differentiation machinery of SHED remains unclear. Recent studies have suggested that mito...

Dental pulp stem cells (DPSCs) from permanent teeth and stem cells from human exfoliated deciduous teeth (SHED) have attracted tremendous interest recently by playing a major role in tissue engineering and regenerative medicine. However, since stem cell technology is still in its infancy, interdisciplinary cooperation between medicine, basic biological research, nanotechnology and materials sci...

objective: in this study, we sought to better understand the immunoregulatory function of stem cells derived from human exfoliated deciduous teeth (shed). we studied the role of the interferon gamma (ifn-γ)-indoleamine 2,3-dioxygenase (ido)-axis in immunoregulation of shed compared to bone marrow derived mesenchymal stem cells (bmmscs) under the same conditions. materials and methods: in this c...

The Journal of Clinical Pediatric Dentistry Volume 33, Number 4/2009 289 INTRODUCTION Tooth banking is based on the firm belief that personalized medicine is the most promising avenue for treating challenging diseases and injuries that could occur throughout lifetime. Stem cell therapy has been used around the world to treat such conditions, and the full promise of stem cell therapy has only be...

Stem cells are the pluripotent cells that have the capacity to differentiate into other specialized cells. Recently, many experiments have been conducted to study the potentiality of stem cells in the tissue regeneration. We report two cases treated utilizing stem cells from human exfoliated deciduous teeth (SHED) in the management of periapical lesions in permanent teeth. Two normal human deci...

Dental pulp represents a promising and easily accessible source of mesenchymal stem cells for clinical applications. Many studies have investigated the use of human dental pulp stem cells and stem cells isolated from the dental pulp of human exfoliated deciduous teeth for bone tissue engineering in vivo. However, the type of scaffold used to support the proliferation and differentiation of dent...