The Staudinger ligation provides a means to form an amide bond between a phosphinothioester and azide. This reaction holds promise for the ligation of peptides en route to the total chemical synthesis of proteins. (Diphenylphosphino)methanethiol is the most efficacious of known reagents for mediating the Staudinger ligation of peptides, providing high (> 90%) isolated yields for equimolar coupl...

Description of two new species and subspecies Bryomima Staudinger, 1900, with 24 colour illustrations 15 genitalia figures.

A novel nucleotide building block for enzymatic synthesis of azide modified DNA and subsequent conjugation via Staudinger ligation was developed.

A new and selective breast cancer-targeting prodrug system is described based on the Staudinger ligation bioorthogonal reaction.

The genus Protarchanara Beck, 1999 is revised. The new genus Hydredes gen. n. (type species Hydredes yakobsoni sp. n.) is described. Three new species, Hydredes yakobsoni sp. n., H. shchetkini sp. n. and Protarchanara mythimnoida sp. n. are described from Central Asia. Two species, Arenostola delattini Wiltshire, 1953 and Hydraecia praecipua Hacker & Nekrasov, 2001 are transferred to the genus ...

Two 5 modified 2'-deoxyuridin triphosphates and a 7 modified 2'-deoxy-7-deazaadenosine were synthesized carrying a terminal azide linked to the base. For probing the sterical influence on incorporation and Staudinger ligation different sized flexible linkers were chosen. All three nucleotides can completely replace their natural counterparts in primer extension as well as polymerase chain react...

A simple and efficient synthesis of N-linked glycoamino acids and glycopeptides from deprotected sugars using the Staudinger reaction.

Two novel modified 2'-deoxyuridine triphosphates carrying an azide functionality linked to the nucleobase were synthesized. For probing the sterical influence on enzymatic incorporation and Staudinger ligation, differently sized flexible linkers were chosen. Both nucleotides can completely replace natural thymidine in primer extension as well as polymerase chain reaction (PCR) using Pyrococcus ...

The Staudinger ligation between an azido-protein and a phosphinothioester-derivatized surface is demonstrated to be an effective means for the site-specific, covalent immobilization of a protein. Immobilization yields of >50% are obtained in <1 min, and immobilized proteins have >80% of their expected activity. No other method enables more rapid immobilization or a higher yield of active protei...