INTRODUCTION Visual analysis is widely used to interpret regional cerebral blood flow (rCBF) SPECT images in clinical practice despite its limitations. Automated methods are employed to investigate between-group rCBF differences in research studies but have rarely been explored in individual analyses. OBJECTIVES To compare visual inspection by nuclear physicians with the automated statistical...

Functional Magnetic Resonance Imaging inherently involves noisy measurements and a severe multiple test problem. Smoothing is usually used to reduce the effective number of multiple comparisons and to locally integrate the signal and hence increase the signal-to-noise ratio. Here, we provide a new structural adaptive segmentation algorithm (AS) that naturally combines the signal detection with ...

Recently, we have introduced an integrated framework that combines wavelet-based processing with statistical testing in the spatial domain. In this paper, we propose two important enhancements of the framework. First, we revisit the underlying paradigm; i.e., that the effect of the wavelet processing can be considered as an adaptive denoising step to "improve" the parameter map, followed by a s...

© 2004 Blackwell Publishing Ltd THE BASIC IDEA Brain responses are recorded using an imaging technique such as fMRI, which allows the repeated measurement of brain activity at hundreds of thousands of points, or voxels, throughout the brain (Fig. 1). Each voxel represents physiological responses from a small anatomical portion of the brain (typically 3 × 3 × 3 mm). The analysis of such data see...

Brain activity is accompanied by changes in cerebral blood flow (CBF) and the differential blood oxygenation that are detectable using functional magnetic resonance imaging (fMRI). The process of identifying brain activation regions can be facilitated by estimating the hemodynamic response function (HRF). There have been some remarkable new developments in statistics to handle this problem. In ...

Results: Statistical parametric mapping (P .05 corrected) and region-of-interest analyses (P .01) showed increased [F]fluorodopa uptake, confined primarily to the ventral striatum in patients with schizophrenia. No reductions in prefrontal cortical [F]fluorodopa uptake Ki were seen in the statistical parametric mapping and region-of-interest analyses, although dorsal anterior cingulate [F]fluor...