Background: Type-2 diabetes is a risk factor for progressive non-alcoholic fatty liver disease and the majority of diabetic patients have blood lipid disorders, so they take statin drugs. Statins have the adverse effects such as liver dysfunction and increase in liver enzymes. The purpose of this study was to compare the liver enzymes in type 2 diabetic patients who are user and non-user of sta...

The most important objectives of this presentation are to attract attention that the associations between oral anti-diabetics drugs and statin at the categories of patients with type 2 obese diabetes mellitus and dyslipidaemia, is dangerous. We know that diabetic patient’s type 2 obese needs diet and oral antidiabetics drugs (biguanide or combination between biguanide and sulfonylurea) to maint...

INTRODUCTION The objective was to examine the role of statins in modulating post-STEMI inflammation and related mortality. METHODS A total of 404 patients with STEMI were reviewed. Demographics, comorbidities, laboratory values, and outcomes were collected. The patients were grouped as STATIN and NOSTAT based on the use of statin drugs at the time of admission. Ninety-seven patients were rece...

Statins are a class of oral drugs that are widely used for treatment of hypercholesterolemia. Recent clinical data suggest that chronic use of these drugs increases the frequency of new onset diabetes. Studies to define the risks of statin-induced diabetes and its underlying mechanisms are clearly necessary. We explored the possible mechanism of statin induced insulin resistance using a well-es...

Increasing the effectiveness and safety of pharmacotherapy hyperlipidemia is an urgent task gastroenterology cardiology. Statin drugs can differ signifi cantly not only in lipid profile normalization, but also spectrum side effects. The paper presents results a comparative chemoreactomic analysis “natural” statins (monacolins K, J, L, simvastatin) synthetic (atorvastatin, fl uvastatin). It important ...

Although the cholesterol-heart hypothesis is often regarded as a dogmatic belief, controversy continues to surround the aetiology and pathogenesis of atherosclerosis. In fact, lowering cholesterol with statin drugs has been shown to reduce cardiovascular risk. However, statins have pleiotropic effects independent of their capacity to lower cholesterol. We highlight that statin drugs exert an im...

Statins are considered to be safe, well tolerated and the most efficient drugs for the treatment of hypercholesterolemia, one of the main risk factor for atherosclerosis, and therefore they are frequently prescribed medications. The most severe adverse effect of statins is myotoxicity, in the form of myopathy, myalgia, myositis or rhabdomyolysis. Clinical trials commonly define statin toxicity ...

Hyperlipidemia is associated with an increased risk of cardiovascular events; reducing low-density lipoprotein cholesterol (LDL-C), the primary target for cholesterol-lowering therapy, lowers the risk for such events. Although bile acid sequestrants were the first class of drugs to show a mortality benefit related to LDL-C lowering, statins are now considered first-line pharmacological therapy ...

Preclinical studies support an anticancer effect of statin drugs, yet epidemiologic evidence remains inconsistent regarding their role in breast cancer primary prevention. Here, we report an updated analysis of the association between statin use and breast cancer incidence in the Nurses' Health Study (NHS) cohort. Postmenopausal NHS participants without a cancer history were followed from 2000 ...