heparin was isolated from whole clam tissue marcia opima . purification of multimilligram quantities of heparin from this tissue sample permitted a thorough examination of its anticoagulant activity characterization, which was partially purified by fractionation by anion exchange chromatography using deae cellulose column. the isolated crude and partially purified fractionated sample showed met...

in our experimental study, 48 rats were divided into six groups in a randomized manner: a (1-3) and b (1-3) groups. a1 and b1 were negative controls. laparotomy was performed and peritoneal inflammation on exposed bowel and peritoneum in a (1-3) and experimental infection induced in peritoneal cavity of b (1-3). each rat of a2 and b2 received 100 iu intraperitoneal standard heparin and each rat...

Physicochemical and anticoagulant characteristics of 27 samples from recent batches of commercially produced unfractionated heparin have been determined as part of the process of establishment of the 5th International Standard Unfractionated Heparin. They have been compared with current heparin standards (European Pharmacopoeia, United States Pharmacopoeia, Chinese), with the 4th International ...

Objective: Heparin and enoxaparin possess anti-inflammatory properties. We compared the effects of these drugs on inflammatory biomarkers in patients with ST-segment Elevated Myocardial Infarction (STEMI). Method: Thirty four patients with STEMI randomly separated in two groups and received standard doses of heparin and enoxaparin. The serum concentration of Serum Amyloid A (SAA), C-Reactive Pr...

Objective: Heparin and enoxaparin possess anti-inflammatory properties. We compared the effects of these drugs on inflammatory biomarkers in patients with ST-segment Elevated Myocardial Infarction (STEMI). Method: Thirty four patients with STEMI randomly separated in two groups and received standard doses of heparin and enoxaparin. The serum concentration of Serum Amyloid A (SAA), C-Reactive Pr...

We have compared the hemorrhagic and antithrombotic effects of a low molecular weight (LMW) heparin fraction and standard heparin in rabbits. Similar LMW heparin fractions have antithrombotic effects when tested in animals, but their hemorrhagic effects relative to standard heparin have not been established. Standard porcine mucosal heparin (mol wt 15,000 daltons) was depolymerized by nitrous a...

heparin- induced thrombocytopenia (hit) is an antibody mediated adverse effect of heparin therapy which is classified into two subtypes, hit i which is non-immune, spontaneously reversible thrombocytopenia and; hit ii which is an autoimmune-mediated adverse effect of heparin therapy. in this case report, we described a 65-year old male patient with hit ii after coronary artery bypass grafting. ...

Objective- Study on the effect of heparin in prevention of abdominal adhesions following abdominal surgery in rat. Design- Experimental design. Animals-Twenty male rats with average weight of 248 ± 5 gr. Procedures- Animals were randomly divided into two equal groups of 10 rats (A and B). After induction of anesthesia, a midline abdominal incision was made and intestines were manipulated ...