نتایج جستجو برای: ssg
تعداد نتایج: 502 فیلتر نتایج به سال:
BACKGROUND Resistance of Leishmania donovani to pentavalent antimonials, the first-line treatment of visceral leishmaniasis (VL), has become a critical issue worldwide. Second-line and new drugs are also not devoid of limitations. Suitable drug-delivery systems can improve the mode of administration and action of the existing antimonials, thus increasing their clinical life. METHODOLOGY/PRINC...
BACKGROUND Alternative treatments for visceral leishmaniasis (VL) are required in East Africa. Paromomycin sulphate (PM) has been shown to be efficacious for VL treatment in India. METHODS A multi-centre randomized-controlled trial (RCT) to compare efficacy and safety of PM (20 mg/kg/day for 21 days) and PM plus sodium stibogluconate (SSG) combination (PM, 15 mg/kg/day and SSG, 20 mg/kg/day f...
Leishmania donovani is an intracellular protozoan parasite that causes visceral leishmaniasis (VL). Antimonials (SSG) have long been the first-line treatment against VL, but have now been replaced by miltefosine (MIL) in the Indian subcontinent due to the emergence of SSG-resistance. Our previous study hypothesised that SSG-resistant L. donovani might have increased in vivo survival skills whic...
Cancer cell resistance limits the efficacy of IFNs. In this study, we show that sodium stibogluconate (SSG) and IFN-alpha synergized to overcome IFN-alpha resistance in various human cancer cell lines in culture and eradicated IFN-alpha-refractory WM9 human melanoma tumors in nude mice with no obvious toxicity. SSG enhanced IFN-alpha-induced Stat1 tyrosine phosphorylation, inactivated intracell...
The aim of this study was to examine the effects of variations in pitch dimensions on pre-adolescent youth soccer players' physiological responses during two different types of small-sided games (SSG). Sixteen young soccer players (age: 13.2 ± 0.6 years; body mass: 52.5 ± 7 kg; height: 163.4 ± 6 cm) participated in this study. They performed 4 vs. 4 stop-ball SSG (SB-SSG) vs. small-goals SSG (S...
The effect, of varying the proportion of binder starch paste (SP) and the disintegrant sodium starch glycolate (SSG), on the compaction behavior of wet granulated acetaminophen (ACM) formulations using a fully instrumented rotary tablet press, was studied. Wet granulation formulations were prepared using ACM, SP as binder (equal to 2.5%, 5% or 10% starch concentration), SSG as disintegrant (0%,...
BACKGROUND Coenzyme A glutathione disulfide (CoA-SSG) was recently isolated from bovine adrenal glands and was shown to be a renal vasoconstrictor. The identification of CoA-SSG in human parathyroid glands and its action on cultured vascular smooth muscle cells (VSMCs) are described here. METHODS AND RESULTS After purification to homogeneity by several chromatographic steps, CoA-SSG was ident...
Small-sided-games (SSGs) seem to be a useful tool for replicating most types of scenarios found in sport competitions, but it is not that clear in female soccer. Game surface and pitch size seem to affect the intensity of SSGs, but no one has yet analysed the influence of these two variables together. The objective of this research was to analyse the metabolic power demands of various SSGs on p...
BACKGROUND Pentavalent antimony is the agent recommended for treatment of cutaneous leishmaniasis (CL). Its use is problematic, because it is expensive and because of the potential for drug-associated adverse effects during a lengthy and painful treatment course. METHODS We tested the efficacy of thermotherapy for the treatment of CL due to Leishmania tropica in a randomized, controlled trial...
Chronic hepatitis C virus (HCV) infection is a worldwide health problem causing serious complications, such as liver cirrhosis and hepatoma. Alpha interferon (IFN-alpha) or its polyethylene glycol-modified form combined with ribavirin is the only recommended therapy. However, an alternative therapy is needed due to the unsatisfactory cure rate of the IFN-based therapy. Using a modified reporter...
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