The area under the ROC curve (AUC) has been widely used to measure ranking performance for binary classification tasks. AUC only employs the classifier’s scores to rank the test instances; thus, it ignores other valuable information conveyed by the scores, such as sensitivity to small differences in the score values. However, as such differences are inevitable across samples, ignoring them may ...

The aim of this meta-analysis was to systematically evaluate the diagnostic accuracy of microRNAs (miRNAs) in distinguishing malignant thyroid lesions from benign ones and to determine the potential of miRNAs as diagnostic biomarkers for thyroid cancer. The random-effect model was used to summarize the pooled estimates of diagnostic accuracy, including sensitivity, specificity, positive likelih...

OBJECTIVES The aim of this study was to systematically evaluate the diagnostic value of cell free DNA (cfDNA) for breast cancer. RESULTS Among 308 candidate articles, 25 with relevant diagnostic screening qualified for final analysis. The mean sensitivity, specificity and area under the curve (AUC) of SROC plots for 24 studies that distinguished breast cancer patients from healthy controls we...

–The area under the curve (AUC) of summary receiver operating characteristic (SROC) is a primary statistical outcome for meta-analysis diagnostic test accuracy studies (DTA). However, its confidence interval has not been reported in most DTA meta-analyses, because no certain methods and packages have provided. In this article, we provide bootstrap algorithm computing AUC. Also, using framework,...

OBJECTIVE MicroRNAs (miRNAs) have become the focus of most recent efforts in cancer research. However, there have been inconsistencies in the literature regarding the suitability of circulating miRNAs for early detection of gastrointestinal cancers. This study aims to assess the diagnostic performance of circulating miRNAs in detection of gastrointestinal cancer through a meta-analysis. METHO...

Background The diagnostic accuracy of diffusion-weighted imaging (DWI) to detect prostate cancer is well-established. DWI provides visual as well as quantitative means of detecting tumor, the apparent diffusion coefficient (ADC). Recently higher b-values have been used to improve DWI's diagnostic performance. Purpose To determine the diagnostic performance of high b-value DWI at detecting prost...

This study was to compare the validity of three pressure ulcer risk tools: Cubbin and Jackson, Braden, and Douglas scales. Data were collected three times per week from 48 to 72 h after admission based on the three pressure ulcer risk assessment scales and skin assessment tool developed by the Panel for the Prediction and Prevention of Pressure Ulcers (1994) from 112 intensive care unit (ICU) p...

Objective To compare the predictive validity of three pressure ulcer risk scales: the Braden scale; the Song and Choi scale; and the Cubbin and Jackson scale and to choose the most appropriate calculator for predicting pressure ulcer risk in the Surgical Intensive Care Unit (SICU) in South Korea. Design Non‐experimental prospective study. Setting A 1,053 bed tertiary educational hospital in Sou...

BACKGROUND Neutrophil CD64 (nCD64) is a promising marker for diagnosing bacterial infections. Several studies have investigated the performance of nCD64 for diagnosing neonatal sepsis and the results are variable. Interest in nCD64 for detecting serious bacterial infections is increasing rapidly. OBJECTIVES The aim of the present study was to carry out a meta-analysis to systematically evalua...

BACKGROUND/AIM The diagnosis of acute small bowel obstruction (ASBO) may be difficult and the decision to operate is based on clinical findings. So far, diagnostic scores (DSs) for ASBO detection have been rarely evaluated. PATIENTS AND METHODS A cohort 1,333 abdominal pain (AAP) patients with 54 patients, were included in study. most significant findings (in multivariate logistic regression an...