OBJECTIVE To investigate whether an intravenously injected cathepsin-B activatable theranostic agent (L-SR15) would be cleaved in and release a fluorescent agent (chlorin-e6) in mouse atheromata, allowing both the diagnostic visualization and therapeutic application of these fluorophores as photosensitizers during photodynamic therapy to attenuate plaque-destabilizing cathepsin-B activity by se...

in order to study the effect of synorhizobium meliloti on growth and nutrients uptake of sesame, a greenhouse test was carried out. the first isolates investigated in iaa and siderophore producing and their ability in solubilizing inorganic phosphates. the results showed that all of isolates were able to produce auxin with different among. the maximum amount of iaa production was 59.5 g ml-1 th...

PURPOSE To assess the levels of quality of life (QoL) in major depressive disorder (MDD) patients treated with either duloxetine or a selective serotonin reuptake inhibitor (SSRI) as monotherapy for up to 6 months in a naturalistic clinical setting mostly in the Middle East, East Asia, and Mexico. PATIENTS AND METHODS Data for this post hoc analysis were taken from a 6-month prospective obser...

OBJECTIVES CEQUEL (Comparative Evaluation of QUEtiapine plus Lamotrigine combination versus quetiapine monotherapy [and folic acid versus placebo] in bipolar depression) was a double-blind, randomized, placebo-controlled, parallel group, 2×2 factorial trial that examined the effect of adding lamotrigine and/or folic acid (FA) to quetiapine in bipolar depression. Lamotrigine improved depression,...

pathogenicity of wheat stem rust was investigated during two cropping seasons of the years 2010 and 2011. towards this end, 47 isogenic lines of wheat stem rust along with 43 cultivars/lines of the crop were tested in field conditions (natural infection) and also in the greenhouse conditions. the results showed, similarity of pathogenicity for plants carring gene/s sr7b, sr8a, sr8b, sr9b, sr9d,...

Abstract Introduction High cognitive arousal—i.e., heightened activity often in the form of perseverative thinking—is a central feature insomnia. Emerging evidence from randomized controlled trials (RCTs) support alleviating arousal as mechanism by which behavioral therapy for insomnia (CBTI) reduces symptoms and depression. However, few RCTs have published CBTI data on outcomes. The present st...

Abstract Introduction Cognitive-behavioral therapy for insomnia (CBTI) is first-line treatment insomnia, but a provider shortage limits access. eHealth technology can increase access to behavioral interventions, and digital CBTI (fully automated programs) are effective. However, >50% of patients do not remit, non-remission linked undertreated cognitive arousal, central feature insomnia. ...