نتایج جستجو برای: square pmt

تعداد نتایج: 130297  

Journal: :Cancer research 2005
Belinda E Peace Kenya Toney-Earley Margaret H Collins Susan E Waltz

The tyrosine kinase receptor Ron has been implicated in several types of cancer, including overexpression in human breast cancer. This is the first report describing the effect of Ron signaling on tumorigenesis and metastasis in a mouse model of breast cancer. Mice with a targeted deletion of the Ron tyrosine kinase signaling domain (TK-/-) were crossed to mice expressing the polyoma virus midd...

Journal: :The Biochemical journal 2007
Katherine M Brendza William Haakenson Rebecca E Cahoon Leslie M Hicks Lavanya H Palavalli Brandi J Chiapelli Merry McLaird James P McCarter D Jeremy Williams Michelle C Hresko Joseph M Jez

The development of nematicides targeting parasitic nematodes of animals and plants requires the identification of biochemical targets not found in host organisms. Recent studies suggest that Caenorhabditis elegans synthesizes phosphocholine through the action of PEAMT (S-adenosyl-L-methionine:phosphoethanolamine N-methyltransferases) that convert phosphoethanolamine into phosphocholine. Here, w...

2012
Rebecca C. Babb Karen A. Homer Jon Robbins Alistair J. Lax

Many bacterial toxins covalently modify components of eukaryotic signalling pathways in a highly specific manner, and can be used as powerful tools to decipher the function of their molecular target(s). The Pasteurella multocida toxin (PMT) mediates its cellular effects through the activation of members of three of the four heterotrimeric G-protein families, G(q), G(12) and G(i). PMT has been s...

Journal: :The Journal of biological chemistry 2010
Shigeki Kamitani Kengo Kitadokoro Masayuki Miyazawa Hirono Toshima Aya Fukui Hiroyuki Abe Masami Miyake Yasuhiko Horiguchi

Pasteurella multocida toxin (PMT) is a virulence factor responsible for the pathogenesis of some forms of pasteurellosis. The toxin activates G(q)- and G(12/13)-dependent pathways through the deamidation of a glutamine residue in the alpha-subunit of heterotrimeric GTPases. We recently reported the crystal structure of the C terminus (residues 575-1285) of PMT (C-PMT), which is composed of thre...

2016
Nathan C. Clemons Shuhong Luo Mengfei Ho Brenda A. Wilson

Pasteurella multocida toxin (PMT), the major virulence factor responsible for zoonotic atrophic rhinitis, is a protein deamidase that activates the alpha subunit of heterotrimeric G proteins. Initial activation of G alpha-q-coupled phospholipase C-beta-1 signaling by PMT is followed by uncoupling of G alpha-q-dependent signaling, causing downregulation of downstream calcium and mitogenic signal...

2005
Belinda E. Peace Kenya Toney-Earley Margaret H. Collins Susan E. Waltz

The tyrosine kinase receptor Ron has been implicated in several types of cancer, including overexpression in human breast cancer. This is the first report describing the effect of Ron signaling on tumorigenesis and metastasis in a mouse model of breast cancer. Mice with a targeted deletion of the Ron tyrosine kinase signaling domain (TK / ) were crossed to mice expressing the polyoma virus midd...

2017
Stefan Carle Thorsten Brink Joachim H. C. Orth Klaus Aktories Holger Barth

The AB-type protein toxin from Pasteurella multocida (PMT) contains a functionally important disulfide bond within its catalytic domain, which must be cleaved in the host cell cytosol to render the catalytic domain of PMT into its active conformation. Here, we found that the reductive potential of the cytosol of target cells, and more specifically, the activity of the thioredoxin reductase (Trx...

2016
Hae-Soo Kwak Chogsom Chimed Sang-Hun Yoo Yoon Hyuk Chang

The objective of this study was to determine the physicochemical and sensory properties of Appenzeller cheese supplemented with different concentrations (0, 1, 2, 3, and 4%, w/w) of powdered microcapsules of tomato extracts (PMT) during ripening at 14℃ for 6 mon. The particle sizes of PMT ranged from 1 to 10 m diameter with an average particle size of approximately 2 m. Butyric acid (C4) concen...

  Background: Skin cancer is a serious public health problem in the world. Its prevalence in many countries has been increased in recent years. This study aimed to assess the effects of a theory-based educational intervention to promote skin cancer preventive behaviors (SCPBs) among rural farmers in Chalderan County, Iran.   Methods: This was a quasi-randomized controlled fiel...

Journal: :Veterinary pathology 1997
S M Gwaltney R J Galvin K B Register R B Rimler M R Ackermann

The effect of Pasteurella multocida toxin (PMT) on porcine osteoclast and osteoblast differentiation was studied using in vitro cell culture systems. When grown in the presence of Vitamin D3, isolated porcine bone marrow cells formed multinucleated cells with features characteristic of osteoclasts. Exposure of bone marrow cells to Vitamin D3 and PMT during growth resulted in formation of increa...

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