Stiff-person syndrome (SPS) is an autoimmune neurological disorder characterized by rigidity of the trunk and proximal limb muscles, intermittent superimposed spasms, and increased sensitivity to external stimuli. It has been more than 50 years since Moerch and Woltman reported the first 14 cases with this syndrome. During the last half century, many autoantibodies discovered, such as anti-glut...

Small proteins (SPs, <=100 amino acids in length) are prevalent in all prokaryotes and eukaryotes. They are known to perform varieties of relevant functions and participate in regulation of various biological processes. Although integrated studies of SPs in prokaryotes and animals have been carried out, the systematic investigation on plant SPs still remains an unwritten story. This is mainly b...

An elevated cholesterol level might lead to cardiovascular disease (CVD). Statins block the cholesterol synthesis pathway in the liver. Atorvastatin is the most widespread statin worldwide and, its chemical synthesis requires toxic catalysts, resulting in environmental pollution. Hence, enzymatic synthesis of atorvastatin is desirable. This process could be done by Lactobacillus kefir ...

An elevated cholesterol level might lead to cardiovascular disease (CVD). Statins block the cholesterol synthesis pathway in the liver. Atorvastatin is the most widespread statin worldwide and, its chemical synthesis requires toxic catalysts, resulting in environmental pollution. Hence, enzymatic synthesis of atorvastatin is desirable. This process could be done by Lactobacillus kefir ...

spark plasma sintering (sps) method, as plasma activated sintering, is a method applicable for rapid sintering of metals and ceramics. owing to the advantage of rapid heating, the alumina ceramics obtained by sps have a grain size and density comparable to those of hot pressed ones. the increase of densification rate may be related to some difference in ion transport characteristics. this study...

case presentation the patient was a 65-year-old female with sps diagnosed 1 year before. assessments were performed, such as range of motion, muscle strength, pain, balance, and functional mobility. she had shoulder pain, with a score of 5/10 on the numerical pain rating scale for both shoulders. moreover, her muscle strength was impaired. although the patient could not maintain an upright posi...

Expansive laminoplasty for ossification of the posterior longitudinal ligament (OPLL) has had favorable outcomes. Many modifications of expansive laminoplasty have been developed, including expansive laminoplasty with and without spinous process spacers (SPS). The purpose of this study was to determine whether surgical outcomes were similar between expansive laminoplasty surgeries with and with...

We demonstrate superluminal light propagation using two frequency multiplexed pump beams to produce a gain doublet in a photorefractive crystal of Ce:BaTiO(3). The two gain lines are obtained by two-wave mixing between a probe field and two individual pump fields. The angular frequencies of the pumps are symmetrically tuned from the frequency of the probe. The frequency difference between the p...

It has recently been shown (Kunik et al., PLOS Comput Biol 2007;3(8):e167) that the occurrence of specific peptides (SPs) on sequences of enzymes allows for accurate EC classification of enzymes. We inquire whether these SPs play important roles in bringing about the enzymatic function. This is assessed by cross-checking the occurrence of SPs on enzymes with Swiss-Prot annotations and PDB spati...

Saw palmetto supplements (SPS) are commonly consumed by men with prostate cancer. We investigated whether SPS fatty acids and phytosterols concentrations determine their growth-inhibitory action in androgen-sensitive LNCaP cells and hamster flank organs. High long-chain fatty acids-low phytosterols (HLLP) SPS ≥ 750 nM with testosterone significantly increased and ≥500 nM with dihydrotestosteron...