Spray dryers are widely used in the chemical, pharmaceutical and food industries to turn liquid products into free flowing powder. To increase the energy efficiency and improve the product quality, the dryer in question combines drying in four stages, instead of single stage drying. In this paper, we present our latest developments within advanced process control for the four-stage spray dryer....

In recent years, there has been growing interest to use computational fluid dynamics (CFD) for exploring dropletparticles interaction under the turbulent flow of air inside spray dryer systems. The final goal is to predict the dried solid particle size and mass flux distributions under the conditions of collision, coalescence and agglomeration of the droplets and particles. The coarse-grained s...

rotary atomizers are commonly used in spray dryers to atomize feed. one destructive effect of wheel rotation is the creation of a vacuum inside the wheel that conducts hot air from the chamber into the wheel and can lead to atomizer blockage and an explosion. the present work determined the air-pumping characteristics of a rotary atomizer with a 50 mm wheel diameter. the vacuum pressure and pow...

We present a technique for fabricating hydrophobic drug nanoparticles using a microfluidic spray dryer. The nanoparticles are formed by evaporative precipitation of the spray in air at room temperature. Using danazol as a model drug, amorphous nanoparticles are yielded with narrow size distribution, 20-60 nm in diameter. As the device geometry allows us to inject two separate solvent streams, t...

This article presents an investigation of the potential of spray and spouted bed technology for the production of dried extracts of Rosmarinus officinalis Linné, popularly known as rosemary. The extractive solution was characterized by loss on drying, extractable matter and total phenolic and flavonoid compounds (chemical markers). The product was characterized by determination of loss on dryin...

In this study a new soluble solid curcumin nanoemulsion powder was prepared using spray-drying technology to improve the solubility and bioavailability of curcumin. The liquid nanoemulsion consisted of curcumin, Capryol 90, Transcutol P, and Cremophor RH40. The solid nanoemulsion was prepared by spray-drying the liquid nanoemulsion in laboratory spray dryer, using lactose as solid carrier. The ...

In this research, an industrial spray dryer was used and the effects of atomizer speed on the physicochemical properties of milk powder, the textural and sensory characteristics of white cheese made from this milk powder were evaluated. For this purpose, whole milk was converted into powder by using three different speeds (10,000, 11,000, and 12,000 rpm). The results showed that by increasing a...

A solid dispersion of the drug can be made using a polymer carrier to improve solubility. Generally, drugs become amorphized when solid dispersion is formed using a polymer carrier. In such high energy conditions, the solubility of the drug molecule is increased. We previously prepared solid dispersion using a spray-drying technique and reported its solubility and crystallinity. In this study, ...