Introduction An economical way to obtain optically active β-lactam derivatives is the use of amino acids as chiral auxiliaries in Staudinger reaction (Bose et al., 1985). This strategy has been used for asymmetric synthesis of bicyclic β-lactam compounds, such as 2-isocephems, from threonine (Tenneson and Belleau, 1980). In addition, β-lactams obtained by this method are useful as versatile int...

The Software Process Measuring Model (SPMM) [14, 15, 16] has been developed at the Faculty of Electrical Engineering in Osijek, Croatia, by the Software Engineering Institute at the University of Osijek, and is based on the CMM (Capability Maturity Model) [3, 13], CMMI (Capability Maturity Model Integration) [2], Bootstrap [1, 2, 4, 10, 12] and SPICE model [3, 7, 8]. It has been developed in co...

The usefulness and value of Multi-step Machine Learning (ML), where a task is organized into connected sub-tasks with known intermediate inference goals, as opposed to single large model learned end-to-end without sub-tasks, presented. Pre-optimized ML models are better performance obtained by re-optimizing the one. selection an from several small candidates for each sub-task has been performed...

Reaching toward a visual target involves at least two sources of information. One is the visual feedback from the hand as it approaches the target. Another is proprioception from the moving limb, which informs the brain of the location of the hand relative to the target even when the hand is not visible. Where these two sources of information are represented in the human brain is unknown. In th...

In this paper, a bulk arrival retrial queueing model with two phases of service symbolically denoted by M/(G1,G2)/1 has been discussed under Bernoulli vacation schedule to explore main ly its steady state behaviour using maximum entropy principle (MEP). We consider that customers arrive in batches according to Poisson distribution and a single server of the system provides his services in two p...

Common Approach to Impact Measurement (Common Approach) is a set of four flexible impact measurement standards designed empower charities, nonprofits, coops, social purpose businesses (collectively referred as organizations or SPOs), and those they serve identify which impacts are most meaningful. These not make more rigorous accurate; rather, useful interoperable, and, eventually, attuned the ...

The impact of combinatorial chemistry of small molecules on the drug discovery process is now widely recognized by the scientific community [1]. Solid-phase organic synthesis (SPOS) is a valuable tool for the generation of structurally diverse compounds for combinatorial libraries. In our work dealing with the solid-phase synthesis of biologically interested compounds, we have developed methodo...

Solid-phase organic synthesis (SPOS) has been established as an important tool for preparative chemistry with a broad range of applications in modern organic synthesis. In very few reaction steps, libraries of molecularly diverse compounds can be synthesized by taking advantage of the efficient removal of excess or unconsumed reagents by extraction and filtration as simple workup operations. Ho...

The article substantiates the importance of including sports holidays in work a coach within organizing judo classes with preschool children. reveals role festival as an effective means pedagogical influence. purpose study was to develop and test program for children section. 42 young judoists at age 5-6 years first year took part study. It is revealed that spos holidays, through creation emoti...