introduction: inflammatory myofibroblastic pseudotumors are initially described in the lung and various extrapulmonary sites such as the orbits, palatine tonsils, ears, gingiva, pterygomaxillary space, and periodontal tissues. these tumors rarely involve the larynx and predilection to the glottis occurs in an indolent manner.   case report this case describes a laryngeal myofibroblastic tumor i...

Introduction: Inflammatory myofibroblastic pseudotumors are initially described in the lung and various extrapulmonary sites such as the orbits, palatine tonsils, ears, gingiva, pterygomaxillary space, and periodontal tissues. These tumors rarely involve the larynx and predilection to the glottis occurs in an indolent manner.   Case Report This case describes a laryngeal myofibroblastic tumor i...

Analysis of benign and malignant mouse skin tumors had previouslyshown that amplification of a mutant H-ras alÃ-eleor loss of the normal alÃ-elewas generally seen only in high grade or spindle cell tumors. The normal:mutant ras gene dosage has been studied directly by polymerase chain reaction amplification of DNA derived from paraffin sections of carcinomas of defined histolÃ3gica!types. Some ...

BACKGROUND In the current study the authors describe the clinicopathologic characteristics of a low grade variant of spindle cell metaplastic tumors of the breast. Previously these tumors have been considered within a larger group recognized as metaplastic carcinoma, including cases with higher grade features. METHODS Breast tumors comprised predominantly of low grade spindle cells, with spar...

Spindle cell neoplasms are defined as neoplasms that consist of spindle-shaped cells in the histopathology. Spindle cell neoplasms can affect the oral cavity. In the oral cavity, the origin of the spindle cell neoplasms may be traced to epithelial, mesenchymal and odontogenic components. This article aims to review the spindle cell neoplasms of the oral cavity with emphasis on histopathology. ...

Follicular dendritic cell sarcomas (FDCS) are spindle lesions that large, slow-growing masses in either nodal or extranodal regions both and originate from B-cell follicles of the lymph nodes. Most tumors cervical nodes, but retroperitoneal mediastinal origins have also been reported. Extranodal areas include soft tissues, skin, tonsils, gastrointestinal tract, liver, spleen. The spleen is an u...

Dear Dr. Bedrossian: Although histological examination is by-and-far considered the gold standard for most soft tissue diagnoses, fine needle aspiration (FNA) is an excellent modality to determine the initial characteristics of the lesion in question. To our knowledge, there have been only two reported cases of ordinary lipoma and spindle-cell lipoma occurring at the same time in the same patie...

CONTEXT Pleomorphic cutaneous spindle cell tumors can be difficult to distinguish solely on histologic grounds. The use of ancillary immunohistochemical studies can greatly assist in this differential diagnosis. OBJECTIVE To review histologic and immunohistochemical aspects of cutaneous spindle cell tumors and discuss a basic panel of markers to assist in the differential diagnosis. DATA SO...

Inflammatory myofibroblastic tumors (IMTs) and gastrointestinal stromal tumors (GISTs) are both spindle cell tumors, and occur rarely in the wall of the urinary bladder. In general, immunostaining allows differentiation of IMTs and GISTs. Most IMTs are positive for anaplastic lymphoma kinase (ALK) and negative for KIT, whereas most GISTs are ALK-negative and KIT-positive. Here, we describe a ca...