When starting the software process improvement (SPI) journey, there are many SPI standards toselect from. Selecting good SPI standards can be a technical problem, from a software engineeringpoint of view, but it can also be a political problem, some standards fitting more with internal politicalagendas than others. As it is well-known that SPI without management commitment can have<...

BACKGROUND Previous reports suggest that beneficial effects of soy on bone quality are due to the estrogenic actions of isoflavone phytochemicals associated with the protein. However, mechanistic studies comparing the effects of soy diet and estrogens on bone, particularly in rapidly growing animals are lacking. METHODOLOGY AND PRINCIPAL FINDINGS We studied the effects of short term feeding o...

Context: Software Process Improvement initiatives have been around for many years with the growing globalisation of software development is making them increasingly important. Objective: The objective of this exploratory research is to gain an in-depth understanding of barriers that can undermine SPI, in the context of Global Software Development, from the perspective of software development pr...

When starting the software process improvement (SPI) journey, there are many SPI standards to select from. Selecting good SPI standards can be a technical problem, from a software engineering point of view, but it can also be a political problem, some standards fitting more with internal political agendas than others. As it is well-known that SPI without management commitment can have disastrou...

Overexpression of the transcription factor Spi-1/PU.1 in mice leads to acute erythroleukemia characterized by a differentiation block at the proerythroblastic stage. In this study, we made use of a new cellular system allowing us to reach graded expression of Spi-1 in preleukemic cells to dissect mechanisms of Spi-1/ PU-1 in erythroleukemogenesis. This system is based on conditional production ...

Previously it was shown that the Ets proteins, PU.1 and Spi-B, exhibit functional redundancy in B lymphocytes. To investigate the possibility that PU.1 or Spi-B or both share overlapping roles with Ets-1 or Elf-1, PU.1(+/-)Ets-1(-/-), PU.1(+/-)Elf-1(-/-), and Spi-B(-/-)Ets-1(-/-) animals were generated. No blood cell defects were observed in these animals except those previously reported for Et...

Acute leukemias are characterized by deregulation of transcriptional networks that control the lineage specificity of gene expression. The aberrant overexpression of the Spi-1/PU.1 transcription factor leads to erythroleukemia. To determine how Spi-1 mechanistically influences the transcriptional program, we combined a ChIP-seq analysis with transcriptional profiling in cells from an erythroleu...

The ETS protein Spi-1/Pu.1 plays a pivotal and widespread role throughout hematopoiesis in many species. This study describes the identification, characterization, and functional analysis of a new zebrafish spi transcription factor spi-1– like (spi-1l) that is expressed in primitive myeloid cells, erythro-myelo progenitor cells, and in the adult kidney. Spi-1l functions genetically downstream o...

In order to define a modern approach for Software Process Improvement (SPI), the SPI Manifesto was developed, discussed, and finalized at the 16 EuroSPI Conference in 2009 in Alcala, Spain. The common understanding gained during the discussion and usage of the manifesto formed a nucleus from which the new ISO/IEC 33014[ISO01] was derived. In parallel to the development of the SPI Manifesto, the...

We investigated the phylogenetic distribution of the SPI-1 and SPI-2 pathogenicity islands in Salmonella spp. SPI-1 was present in representatives of all eight subspecific groups, but no SPI-2-hybridizing sequences were detected in group V (S. bongori). Our data suggest that SPI-2 was acquired by S. enterica after its split from S. bongori.