نتایج جستجو برای: sphingosine kinase 1 phosphate

تعداد نتایج: 2966039  

Journal: :The Journal of biological chemistry 2008
Francisco Leocata Nieto Lucila G Pescio Nicolás O Favale Ana M Adamo Norma B Sterin-Speziale

The present report was addressed to study the influence of sphingolipid metabolism in determining cellular fate. In nonstimulated proliferating Madin-Darby canine kidney (MDCK) cells, sphingolipid de novo synthesis is branched mainly to a production of sphingomyelin and ceramide, with a minor production of sphingosylphosphocholine, ceramide 1-phosphate, and sphingosine 1-phosphate. Experiments ...

Journal: :Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2013

Journal: :Journal of Pharmacology and Experimental Therapeutics 2015

Journal: :Molecular microbiology 2013
Ou Zhang Fong-Fu Hsu Wei Xu Mattie Pawlowic Kai Zhang

Sphingosine kinase is a key enzyme in sphingolipid metabolism, catalysing the conversion of sphingosine or dihydrosphingosine into sphingosine-1-phosphate or dihydrosphingosine-1-phosphate respectively. In mammals, sphingosine-1-phosphate is a powerful signalling molecule regulating cell growth, differentiation, apoptosis and immunity. Functions of sphingosine kinase or sphingosine-1-phosphate ...

Journal: :The Journal of Experimental Medicine 1999
Eva E. Prieschl Robert Csonga Veronica Novotny Gary E. Kikuchi Thomas Baumruker

Over the last few years, sphingolipids have been identified as potent second messenger molecules modulating cell growth and activation. A newly emerging facet to this class of lipids suggests a picture where the balance between two counterregulatory lipids (as shown in the particular example of ceramide and sphingosine-1-phosphate in T lymphocyte apoptosis) determines the cell fate by setting t...

Journal: :Journal of Investigative Dermatology 2022

Extrinsic factors, such as air pollutants and ultraviolet irradiation (UVR), accelerate premature aging, a correlation between levels of skin aging symptoms has been reported. Diesel particulate matter, major source pollution, helps initiate some diseases, including diseases. We recently demonstrated that diesel extract (DPE) activates nicotinamide adenine dinucleotide phosphate (NADPH) oxidase...

Journal: :American Journal of Respiratory and Critical Care Medicine 2014

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2002
Nathalie Auge Virginie Garcia Françoise Maupas-Schwalm Thierry Levade Robert Salvayre Anne Negre-Salvayre

OBJECTIVE Oxidized low-density lipoprotein (oxLDL)-induced smooth muscle cell (SMC) proliferation requires the coactivation of various signaling pathways, namely sphingomyelin/ceramide/sphingosine-1-phosphate, epithelial growth factor receptor (EGFR), and phosphoinositide 3-kinase (PI-3K) pathways. This study aimed to clarify the respective role and the hypothetical cross-talk between sphingomy...

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