ABSTARCT:Emulsion Solovent Diffusion (EDS) technique combines crystallization and agglomeration directly to generate spherical agglomerates with improved micromeretic properties, thus obviating need for further processing by granulation and agglomeration. The present study was focused on spherical crystallization of an antifungal drug Gresiofulvine (GRV) using above mentioned ESD technique in w...

Pelletization is an agglomeration process that converts fine powders or granules of bulk drugs and excipients into small, free flowing, spherical or semi-spherical units, referred to as pellets. This review outlines manufacturing of spherical pellets. The manufacturing techniques include Drug layering, Extrusion-Spheronization, Cryopelletization, Compression, Balling, Hot-Melt Extrusion Technol...

Direct tabletting technique is the modern and the most efficient process used in tablet manufacturing which has been successfully used for various drugs. But the process strongly depends upon the quality of the crystals used. For improvement of direct compression properties of different poorly soluble drugs Kawashima and their coworkers developed the spherical crystallization technique in 1986,...

Objective(s):This study dealt with the wet agglomeration process in which a small quantity of binder liquid was added into a suspension of crystals, directly in the stirring vessel where the crystallization took place. The purpose of this investigation was evaluation of the effect of temperature on the agglomeration process in order to gain insight into the mechanism of the formation of the agg...

We demonstrate the photophoretic trapping of more than several hundreds of absorbing particles by tapered-ring optical traps diffracted from a circular aperture. The experiments with different laser powers show the influence of air flow acting on particles. Three kinds of particles with different densities (about 1~7 g/cm(3)) and different shapes (spherical, non-spherical) can be trapped. The n...

Nimodipine (NMP), a Ca channel blocker, has a low oral bioavailability due to poor solubility and insufficient dissolution rate. In order to improve the same, various techniques were employed viz., evaporative precipitation into aqueous solution (EPAS), spherical agglomeration (SA) and solid dispersion using solvent evaporation and meltmixing. Formulations so prepared were characterised by diff...

OBJECTIVES This study dealt with the wet agglomeration process in which a small quantity of binder liquid was added into a suspension of crystals, directly in the stirring vessel where the crystallization took place. The purpose of this investigation was evaluation of the effect of temperature on the agglomeration process in order to gain insight into the mechanism of the formation of the agglo...

c 5 Abstract In Part I of this series of papers, it was shown that a definite amount of air had to be present in a laboratory mixing unit which produced a moderate shear rate in order to form compact, spherical agglomerates in an aqueous suspension of moderately hydrophobic coal using heptane or hexadecane as an agglomerant. In this paper, the effects of different amounts of air including disso...