alized as a cyclic process in which the cell prog resses through a sequence of molecular events in volving the timely synthesis or activation of spe cific macromolecules. The present study concerns the mechanisms underlying the initiation of DNA synthesis. With use of synchronized cultures of HeLa (1@) it was demonstrated that DNA replication occurs only after a specific triggering event and th...

The reputed localization of tetracycline in human and animal tumors suggested that chemically stable, high-spe cific-activity tritiated tetracycline (TTC) might have antineoplastic therapeutic potential. Direct therapeutic effects were tested in two transplanted tumor lines in rats, and the localizing properties of TTC were measured in 30 trans planted tumor lines in rats and mice and in 23 spo...

ease has been a widespread nuclear medicine procedure for 20 years. During this time, numerous reports of the diagnostic worth of this test have been published (1—38), with reported sensitivity values ranging from 60 to 98%, and specificity values from 64 to 99%. Although many series have consisted of a small number of patients, and consequently may have large uncertainties, several ne ports ...

Product development is a knowled ge intensive process. It is widel y recognized as a m echanism that produces fi rms to learn, to enter new technological areas, and to deal more effectively with market uncertainty. Since technology management has beco me ingrained within the field of knowledge management, product development has be en viewed and studied from a knowledge management perspective. ...

Arabibarbus grypus (Heckel, 1843), which naturally lives in the Euphrates and Tigris River systems is endemic, an economically important fish species consumed by humans. Since population of this species, hunted both fishermen local peo-ple, decreasing day day, its genetic characteristics need to be determined. This study aims determine A. samples living Great Zab based on sequence analysis mtDN...

SUMMARY A malignant intraocular neoplasm that resembled human retinoblastomas was produced in CD rats by injection of human adenovirus type 12. Fluid (0.01 ml), containing adenovirus type 12, l0@@ 50% tissue culture infective doses/mI, from culture fluids ofhuman embryo kidney cells was injected into the vitreous cavity of each newborn rat. Three of 35 virus-injected rats developed an intraocul...

Friend, Moloney, and Rauscher (FMR) viruses were in cubated with either normal serum or with sera from C57BL/6 mice immunized with syngeneic Friend, Moloney, or Rauscher virus-induced lymphomas. The mixtures were inoculated into newborn BALB/c mice, and the development of lymphomas was followed. The oncogenicity of all 3 viruses was effectively neutralized by each of the antisera. The results s...

The binding of estradiol to nuclear fractions extracted from human breast carcinomatous tissue was demonstrated. The material, which was extracted with KCI, had an approximate molecular weight of 37,000 and bound estradiol with both high and low affinity (K^ = 1 nM, type A receptors; K¿& 30 nw, type B receptors) as calculated according to the method of Scatchard. Competition studies indicated ...

MATERIALS AND METHODS Estramustine phosphate (0.01 to 0.5 HIM),an estradici mustard derivative used in the therapy of prostatic carcinoma, inhibited the assembly of brain microtubule proteins in vitro and disassem bled preformed microtubules. In the presence of estramustine phosphate, the minimum microtubule-protein concentration suf ficient for the assembly of microtubules was increased. Low c...

The article makes predictions about dataism, noting disagreements over the definition, highlighting tendency to perceive it as a problematic threat humanity. Dataism is considered in terms of spe-cific religious traits, construction faith and trust algorithms, formation groups specialists accumulation symbolic power. Pierre Bourdieu's sociology religion theoretical frame-work used study worldvi...