objective(s):neurotoxicity of anticancer drugs complicates treatment of cancer patients. vinblastine (vbl) is reported to induce motor and cognitive impairments in patients receiving chronic low-dose regimen. materials and methods: the effects of vbl treatment on motor, learning and memory functions of male and female wistar rats were studied by behavioral related tests. animals were given chro...

diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the humans and experimental animals. due to the anti-diabetic and antioxidant activity of pelargonidin (pg), this research study was conducted to evaluate the efficacy of chronic oral pg on alleviating learning and memory disturbance in streptozotocin-diabetic rats. male wistar rats were divided into...

background and objective: based on the effect of chronic metabolic diseases including diabetes mellitus on the learning and memory, this study was designed to assess the usefulness of administration of salvialonic acid b on lessening of learning and memory deficits in streptozotocin (stz)-diabetic rats. materials and methods: male wistar rats were allocated into control, salvialonic acid b-trea...

background sildenafil (viagra) has been introduced to treat erectile dysfunction by acting as phosphodiesterase 5 inhibitor and hence accumulation of guanosine cyclic monophosphate (cgmp). on the other hands, the nitric oxide/cgmp signaling pathway has crucial role in synaptic plasticity processes like long-term potentiation (ltp) in the central nervous system considered as a model of learning ...

introduction: many people with amnesia would like to try herbal therapies. ginkgo biloba is one of the most popular herbs which is used to treat amnesia. the beneficial effects of this plant, however, has not been scientifically assessed yet. although, there have been some reports on the memory enhancement effect of ginkgo biloba, the mechanism of its action is not yet explained well. consideri...

objective(s): crocin influences many biological functions including memory and learning. the present study was aimed to investigate the effects of crocin on learning and memory impairments in streptozotocine-induced diabetic rats. materials and methods: diabetes was induced by intraperitoneal (ip) injection of streptozotocin (stz, 45 mg/kg). transfer latency (tl) paradigm in elevated plus-maze ...

previous studies have shown that ascorbic acid (aa) plays a crucial role in mammalian brain as avitamin and neuronal modulator. there is increasing evidence indicating that dopaminergic system and aacould affect learning and memory processes. in addition, vitamin c acts as a dopamine antagonist in thebrain. the aim of the present study was to evaluate the intra-hippocampal co-administration of ...

background and objective: temporal lobe epilepsy (tle) usually leads to memory deficit. in this study, we tried to assess the effect of withania somnifera extract on the impaired learning and memory in the intrahippocampal kainate model of tle in the rat. materials & methods: male rats (n=32) were divided into sham, extract+sham, kainite, and kainite+extract. for induction of epilepsy, uni...