hydroalcoholic extract of pycnocycla spinosa is a relaxant of rat ileum and inhibits diarrhea in mice. as p. spinosa extract has spasmolytic activity on ileum, it could also affect other smooth muscles like bladder. therefore, the aim of this study was to determine the effect of p. spinosa extract on rat bladder contraction. in an in vitro study, the effects of p. spinosa extract, nifedipine an...

onion (allium cepa) bulb from liliaceae has antioxidant, spasmolytic and antihypertensive activities. the aim of present study was to investigate the antispasmodic effect of onion peel on rat ileum contractility. onion peel powder was extracted by maceration in 70% alcohol for 72 h. a terminal portion of ileum from male wistar rat was dissected and its contractions were recorded isotonically in...

Seven new compounds have been synthetized in satisfactory yields (51-78 %) through the treatment of mesoionic 1,3-thiazolium-5-thiolate (4a-d) and 1,3,4-thiadiazolium- 5-thiolate (10a,b) with chloroacetic acid or methyl iodide: 1,3,4-thiadiazolium-5-methylthio- (11) and 5-thioacetate (12). The structure of the title compounds was elucidated by elemental analysis, IR, (1)H and (13)C NMR spectros...

BACKGROUND AND OBJECTIVES The current investigation was carried out to explore the pharmacological basis of the crude extract of Conyza bonariensis (Cb.Cr) for its use in constipation and diarrhea. MATERIALS AND METHODS The plant extract of Conyza bonariensis (C. bonariensis) was prepared, isolated guinea-pig ileum and rabbit jejunum preparations were used to evaluate its gut modulator effect...

INTRODUCTION Jasonia glutinosa is an endemic plant species of the Iberian Peninsula and Southern France traditionally used in infusions as a spasmolytic; this plant is also known as "té de roca" (rock tea) but there is no scientific evidence about the effects of this plant. AIM To evaluate the spasmolytic effect of rock tea. METHODS We have studied the in vitro effect of a rock tea extract ...

Antibacterial activity on ATCC strains of Escherichia coli, Salmonella enterica, Salmonella enteritidis, and Salmonella choleraesuis and spasmolytic effect on contraction on rat ileum trips were determinate. Eight organic extracts (hexanic and methanolic) of albedo (mesocarp) and flavedo (pericarp) of two varieties (Valencian and National) of Citrus sinensis (L.) Osbeck of Yucatán, México, were...