Objective: Naftopidil (NAF) is a selective alpha1-adrenergic receptor antagonist with nearly 20% bioavailability due to poor aqueous solubility, permeability, and extensive first-pass metabolism. To improve the of NAF, solid lipid nanoparticles (SLN) NAF were prepared. Methods: SLNs prepared using solvent emulsification/evaporation method excipients Compritol 888 ATO Poloxamer 188. Formulation ...

copper (ii) phthalocyanine and 2,9,16,23 tetrakis nitro copper (ii) phthalocyaninehas been synthesized respectively from phthalonitrile and 4-nitro phthalonitrile under solvent-free condition using two different catalystsovernanodimensionalzeolites. 4-nitro phthalonitrile synthesized from phthalimide in three steps. the newly prepared compounds have been characterized by ir, uv-vis, 1hnmr and m...

highly active cu (ii) complex with 1,4-dihydroxy anthraquinone as a cheap and accessable ligand could be used as a catalyst for the preparation of structurally different propargylamines from a one-pot, three-component reaction of terminal alkynes, aldehydes, and secondary amines with high yields under solvent-free conditions. the 1,4-dihydroxy anthraquinone is a very efficient cu(ii) scavenger ...

copper (ii) phthalocyanine and 2, 9, 16, 23 tetrakis nitro copper (ii) phthalocyanine has been synthesized respectively from phthalonitrile and 4-nitro phthalonitrile under solvent-free condition using two different catalysts over nanodimensional zeolites. 4-nitro phthalonitrile synthesized from phthaimide in three steps. the newly prepared compounds have been characterized by ir, uv-vis,1h nm...

this work described a simple and efficient synthesis of dialkyl 3-(alkylamino)-1-aryl-1h-pyrazole-4,5-dicarboxylates via a three component reaction between arylhydrazine, alkylisocyanid and dialkylacetylenedicarboxylates in the presence of phenylisocyanate and α-fe2o3 nanoparticles. eco friendly, solvent-free conditions, excellent yields, and short reaction times, inexpensive and readily availa...

The biological properties of a neutrophil-activating factor (NAF), which was recently identified as a novel peptide of approximately 6,000 mol wt, are described. NAF is produced de novo by human blood monocytes upon stimulation with LPS, PHA, and Con A. It induces two main responses in human neutrophils, i.e., exocytosis (release from specific granules in normal, and from specific and azurophil...

Battery sustainability is often neglected in favor of higher performance and economic efficiency battery technology. The standard electrode containing the use binder toxic solvent has a detrimental impact on environment. For first time, sustainable free-standing carbonized silk anode prepared from woven biomass waste. unique mechanical structural properties surface functionality make this mater...

nano sulfated titania was tested as solid acid heterogeneous catalyst for the synthesis of 4-(trifluoromethyl) coumarin and coumarin derivatives under solvent-free condition. factorial design evidenced a positive effect of reaction temperature, amount of catalyst, and solvents.  this nano-sized sulfated titania has been prepared by a sol-gel hydrothermal process. the prepared sulfated titania s...

the use of methanesulfonic acid as a brønsted acid for direct ortho-acylation of phenols and naphthols proves to be a convenient, more general and direct route to various hydroxyaryl ketones. the route is regioselective, leading to ortho c-acylated products in satisfactory to high yields in most cases. the solvent free reactions described below exhibited environmentally benign in terms of faste...

a condensation of various isatins with indole derivatives has been carried out in the presence of 1,3-dibromo-5,5-dimethylhydantoin (dbdmh) as catalyst at 50 °c in ethanol in order to form 3,3-bis(indolyl) oxindoles. the products were obtained within 20-90 min by 70-96% yields. the efficacy of the procedure has been confirmed by catalyzing the condensation reaction of pyrrole which was used as ...