This paper describes the enhancement of dissolution rate of nifluminic acid by spray dry process, as a solid dispersion method using polyvinylpyrrolidone (PVP C-15) as a water soluble polymer. Using solid dispersions as a well-known principle on an industrial scale, it has to be combined with low-cost and repetable manufacturing method. Therefore, the aim of the authors was the amorphisation of...

Solid dispersion refers to the dispersion of one or more active ingredients in an inert carrier in a solid state, frequently prepared by the melting method, solvent method, or fusion solvent method. The oral bioavailability of poorly water soluble drug remains as the most challenging aspects of drug development. Solid dispersion approach is to reduce particle size, therefore increases the disso...

objective(s):solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. the aim of this study was to compare the effect of polyvinylpyrrolidone k30 (pvp) and poloxamer-188 (plx) as carrier in solid dispersion formulations of celecoxib (clx). materials and methods: solid dispersions of clx:pvp or clx:plx were prepared at different r...

the effect of mixing on rheological behavior of 6% wt epoxy-clay nanocomposites was studied. the mixing processes were carried out by low shear mixer, homogenizer and ultrasonic and combination of different mixing techniques at medium and maximum power. all these methods led to intercalated structure. the xrd results showed that the ultrasonic has the best effect on dispersion while a low shear...

The present study aims to experiment the solid dispersion of poorly water soluble drug itraconazole as model drug by spray drying method with the use of PEG/HPMC polymer blends, the influence of polymer compatibility on the degree of molecular dispersion of itraconazole solid dispersions are prepared by ternary mixing and polymer blends are also evaluated for DSC, XRD and in vitro dissolution t...

the present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of poorly water soluble bioactive constituent patchouli alcohol (pa) that can be used for the preparation of immediate release pellets formulation. two commercially available grades poloxamer 188 (p 188) and poloxamer 407 (p 407) were selected, and solid dispersions (sds) conta...

Solid dispersion particles of carvedilol (CAR) were prepared with porous silica (Sylysia 350) by the solvent evaporation method in a vacuum evaporator to ensure an effective pore-filling procedure. Two sets were prepared, each with various amounts of CAR in solid dispersions, and with the pore-filling process differing each time. Set A was prepared by a one-step filling method and set B by a mu...

Objective: The aim of the present study was to develop and evaluate the monolithic osmotic tablet (MOT) composed of the solid dispersion of ketoprofen (KETO), a poorly water-soluble drug. Solid dispersion technique is generally used for immediate release, as this maximizes the amount of drug absorbed. Sustained release may be obtained by combining solid dispersion technique with MOT so as to in...

Prednisolone is a safe antiinflammatory agent for the treatment of inflammatory diseases. To improve the aqueous solubility of the drug and dissolution rate, the complexation of prednisolone with skimmed milk was studied. A physical mixture and solid dispersion of prednisolone with skimmed milk were prepared. The lyophilization method was used to prepare the solid dispersion. Detection of inclu...

in order to enhance in vitro dissolution and content uniformity of poorly soluble drug glimepiride by preparing solid dispersions using modified solvent fusion method, solid dispersions of drug were prepared by modified fusion solvent method using peg 6000 and pvp k25 (as carrier). eight batches (f1-f8) were prepared by factorial design (23) by taking three factors i.e. the concentration of: dr...