Human brain imaging studies from various clinical cohorts show that chronic pain is associated with large-scale brain functional and morphological reorganization. However, how the rat whole-brain network is topologically reorganized to support persistent pain-like behavior following neuropathic injury remains unknown. Here we compare resting state fMRI functional connectivity-based whole-brain ...

A single unicast index coding problem (SUICP) with symmetric neighboring interference (SNI) has equal number of K messages and K receivers, the kth receiver Rk wanting the kth message xk and having the side-information Kk = (Ik∪xk) , where Ik = {xk−U , . . . , xk−2, xk−1}∪{xk+1, xk+2, . . . , xk+D} is the interference with D messages after and U messages before its desired message. The single u...

Pain and depression often co-occur, but the underlying mechanisms have not been elucidated. Here, we used the spared nerve injury (SNI) model in mice to induce both neuropathic pain and depression-like behavior. We investigated whether brain interleukin (IL)-1 signaling and activity of kynurenine 3-monoxygenase (KMO), a key enzyme for metabolism of kynurenine into the neurotoxic NMDA receptor a...

A single unicast index coding problem (SUICP) with symmetric and consecutive interference (SCI) has K messages and K receivers, the kth receiver Rk wanting the kth message xk and having interference Ik = {xk−U−m, . . . , xk−m−2, xk−m−1}∪ {xk+m+1, xk+m+2, . . . , xk+m+D} and side-information Kk = (Ik∪xk) . In this paper, we derive a lowerbound on the broadcast rate of single unicast index coding...

SNi-like mechanisms, which involve front-face leaving group departure and nucleophile approach, have been observed experimentally and computationally in chemical and enzymatic substitution at α-glycosyl electrophiles. Since SNi-like, SN1 and SN2 substitution pathways can be energetically comparable, engineered switching could be feasible. Here, engineering of Sulfolobus solfataricus β-glycosida...

BACKGROUND Clinical and experimental studies of neuropathic pain support the hypothesis that a functional coupling between postganglionic sympathetic efferent and sensory afferent fibers contributes to the pain. We investigated whether neuropathic pain-related behavior in the spared nerve injury (SNI) rat model is dependent on the sympathetic nervous system. RESULTS Permanent chemical sympath...

BACKGROUND Plastic changes in the anterior cingulate cortex (ACC) are critical in the pathogenesis of pain hypersensitivity caused by injury to peripheral nerves. Cdh1, a co-activator subunit of anaphase-promoting complex/cyclosome (APC/C) regulates synaptic differentiation and transmission. Based on this, we hypothesised that the APC/C-Cdh1 played an important role in long-term plastic changes...

UNLABELLED Because γ cameras are generally susceptible to environmental conditions and system vulnerabilities, they require routine evaluation of uniformity performance. The metrics for such evaluations are commonly pixel value-based. Although these metrics are typically successful at identifying regional nonuniformities, they often do not adequately reflect subtle periodic structures; therefor...

BACKGROUND Social defect and chronic pain are 2 major health problems and recent data has demonstrated that they generally exist concurrently. However, a powerful evaluation model on the behavioral change is lacking. This study was designed to evaluate the behavioral curves using a statistically modeled trajectory analysis in neuropathic animals with or without social defect exposure. MATERIA...

A single unicast index coding problem (SUICP) with symmetric neighboring interference (SNI) has equal number of K messages and K receivers, the kth receiver Rk wanting the kth message xk and having the side-information Kk = (Ik ∪ xk) , where Ik = {xk−U , . . . , xk−2, xk−1} ∪ {xk+1, xk+2, . . . , xk+D} is the interference with D messages after and U messages before its desired message. Maleki, ...