An exposition on the use of O’Sullivan penalized splines in contemporary semiparametric regression, including mixed model and Bayesian formulations, is presented. O’Sullivan penalized splines are similar to P-splines, but have the advantage of being a direct generalization of smoothing splines. Exact expressions for the O’Sullivan penalty matrix are obtained. Comparisons between the two types o...

Non parametric regression methods can be presented in two main clusters. The one of smoothing splines methods requiring positive kernels and the other one known as Nonparametric Kernel Regression allowing the use of non positive kernels such as the Epanechnikov kernel. We propose a generalization of the smoothing spline method to include kernels which are still symmetric but not positive semi d...

conclusions the use of smoothing methods helps us to eliminate non-linear effects but it is more appropriate to use cox proportional hazards model in medical data because of its’ ease of interpretation and capability of modeling both continuous and discrete covariates. also, cox proportional hazards model and smoothing methods analysis identified that age at diagnosis and tumor size were indepe...

Smoothing splines provide flexible nonparametric regression estimators. However, the high computational cost of smoothing splines for large datasets has hindered their wide application. In this article, we develop a new method, named adaptive basis sampling, for efficient computation of smoothing splines in super-large samples. Except for the univariate case where the Reinsch algorithm is appli...

A general version of multivariate smoothing splines with correlated errors and correlated curves is proposed. A suitable symmetric smoothing parameter matrix is introduced, and practical priors are developed for the unknown covariance matrix of the errors and the smoothing parameter matrix. An efficient algorithm for computing the multivariate smoothing spline is derived, which leads to an effi...

In this paper, a class of Bayesian hierarchical disease mapping models with spline smoothing are motivated and developed for sequential disease mapping and for surveillance of disease risk trends and clustering. The methodological development aims to provide reliable information about the patterns (both over space and time) of disease risk and to quantify uncertainty. Bayesian disease mapping m...

In this paper, a recursive smoothing spline approach for contour reconstruction is studied and evaluated. Periodic smoothing splines are used by a robot to approximate the contour of encountered obstacles in the environment. The splines are generated through minimizing a cost function subject to constraints imposed by a linear control system and accuracy is improved iteratively using a recursiv...