نتایج جستجو برای: skin permeability rate

تعداد نتایج: 1179169  

Jianxue Yang Liandong Hu Qiaofeng Hu,

Objective(s):The objective of this study was to find a stable microemulsion vehicle for transdermal delivery of ibuprofen to improve the skin permeability. Materials and Methods: Microemulsion was prepared using different sorts of oils, surfactants and co-surfactants. Pseudo-ternary phase diagrams were used to evaluate the microemulsion domain. The effects of oleic acid and surfactant mixture o...

Journal: :Journal of biophotonics 2010
Mohamad G Ghosn Narendran Sudheendran Mark Wendt Adrian Glasser Valery V Tuchin Kirill V Larin

Topical trans-dermal delivery of drugs has proven to be a promising route for treatment of many dermatological diseases. The aim of this study is to monitor and quantify the permeability rate of glucose solutions in rhesus monkey skin noninvasively in vivo as a primate model for drug diffusion. A time-domain Optical Coherence Tomography (OCT) system was used to image the diffusion of glucose in...

2015
Vinicius M. Alves Eugene Muratov Denis Fourches Judy Strickland Nicole Kleinstreuer Carolina H. Andrade Alexander Tropsha

Skin permeability is widely considered to be mechanistically implicated in chemically-induced skin sensitization. Although many chemicals have been identified as skin sensitizers, there have been very few reports analyzing the relationships between molecular structure and skin permeability of sensitizers and non-sensitizers. The goals of this study were to: (i) compile, curate, and integrate th...

2004
Seyed Alireza Mortazavi Reza Aboofazeli

Achieving a desirable percutaneous absorption of drug molecule is a major concern in formulating dermatological products. The use of penetration enhancers could provide a successful mean for this purpose. The aim of this study was to evaluate the effect of incorporating a few common penetration enhancers (in different concentrations) into a 0.5% w/w piroxicam (model drug) gel formulation, on th...

Journal: :The Journal of General Physiology 1963
Peter F. Curran Francisco C. Herrera William J. Flanigan

A method has been developed for determining unidirectional Na fluxes across the two faces of the transporting cells in the frog skin. The method has been used to investigate the location of the sites at which Ca and anti-diuretic hormone act to alter the rate of active Na transport across the skin. The results have indicated that the primary effect of both agents is on the Na permeability of th...

Journal: :Journal of biomedical nanotechnology 2010
Yeu-Chun Kim Peter J Ludovice Mark R Prausnitz

Magainin antimicrobial peptide has been shown to increase skin permeability by perturbing stratum corneum lipids in the skin. In this study, we hypothesized that skin permeation enhancement depends on peptide structure. We therefore measured skin permeability enhancement by modified magainin derivitives and 20 different antimicrobial peptides in a formulation containing ethanol and N-lauroyl sa...

Journal: :jundishapur journal of natural pharmaceutical products 0
eskandar moghimipour nanotechnology research center, ahvaz jundishapur university of medical sciences, ahvaz, ir iran; department of pharmaceutics, faculty of pharmacy, ahvaz jundishapur university of medical sciences, ahvaz, ir iran anayatollah salami nanotechnology research center, ahvaz jundishapur university of medical sciences, ahvaz, ir iran; department of pharmaceutics, faculty of pharmacy, ahvaz jundishapur university of medical sciences, ahvaz, ir iran; corresponding author: anayatollah salami, department of pharmaceutics, faculty of pharmacy, ahvaz jundishapur university of medical sciences, ahvaz, ir iran. tel: +98-6133738381 mahsa monjezi department of pharmaceutics, faculty of pharmacy, ahvaz jundishapur university of medical sciences, ahvaz, ir iran

materials and methods liposomes were prepared by thin film method using soya lecithin and cholesterol. physicochemical characteristics of the liposomes such as, particle size, drug encapsulation efficiency were determined. also, drug release and in vitro skin permeability through rat skin were evaluated using franz diffusion cells. results the results showed that the maximum drug encapsulation ...

Journal: :The Journal of General Physiology 1964
Marcelino Cereijido Francisco C. Herrera William J. Flanigan Peter F. Curran

The effects of changes in Na concentration of the bathing solutions on some transport and permeability properties of the isolated frog skin have been examined. Rate coefficients for unidirectional Na movements across the two major barriers in the skin have been estimated as functions of Na concentration. The results indicate that the "apparent Na permeability" of the outer barrier of the skin d...

Journal: :the iranian journal of pharmaceutical research 0
behzad sharif makhmalzadeh school of pharmacy, ahvaz jundishapur university of medical sciences, ahvaz, iran. shiva torabi school of pharmacy, ahvaz jundishapur university of medical sciences, ahvaz, iran. armita azarpanah school of pharmacy, ahvaz jundishapur university of medical sciences, ahvaz, iran.

the topical delivery of non-steroidal anti-inflammatory drugs (nsaids) such as ibuprofen has been explored as a potential method of avoiding the first pass effects and the gastric irritation, which may occur when used orally. ibuprofen is formulated into many topical preparations to reduce the adverse effects and simultaneously avoid the hepatic first-pass metabolism as well. however, it is dif...

Journal: :Ultrasound in medicine & biology 2009
Jyoti Gupta Mark R Prausnitz

The SonoPrep(R) ultrasonic skin permeation system is used clinically to increase skin permeability for rapid, noninvasive delivery of local anaesthetics. This study tested the hypothesis that sonication can generate a long-lived increase of skin permeability for continuous transdermal drug delivery and diagnostic metabolite extraction. To accomplish this, the volar forearm skin of ten healthy a...

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