warfarin-induced skin necrosis (wisn) is a rare complication of anticoagulant therapy associated with a high incidence of  morbidity and mortality requiring immediate drug cessation. at particular risk are those with various thrombophilic abnormalities, especially when warfarinisation is undertaken rapidly with large loading doses of warfarin. cutaneous findings include petechiae that progress ...

Camels showed clinical signs of contagious skin necrosis (CSN), with or without trypanosomosis, were subjected to study. The following samples were collected; sterile bacteriological swabs from skin necrosis area, whole blood samples for hematological analysis and for diagnosis of trypanosomosis, and serum for measuring lipid peroxidation product (Malondialdehyde, MDA). The bacteriological exam...

Warfarin-induced skin necrosis is an infrequent complication occurring in individuals under warfarin treatment who have a thrombophilic history or after administration of large loading doses of warfarin particularly without simultaneous initial use of heparin. A 62-year-old lady developed skin necrosis 4 days after initiating warfarin therapy of 5 mg daily without initial co-administration of h...

Dear editor, Anticoagulant-induced skin necrosis is a rare and serious complication of treatment with these commonly prescribed drugs. Few cases of heparin induced skin necrosis have been reported in literature and only a small number of them was attributed to enoxaparin (1). We report a case with a delayed diagnosis and fatal outcome. A 78-year-old obese woman with history of hyper-tension, po...

A case of skin necrosis at the sites of injection of subcutaneous heparin is described. The patient went on to develop heparin-induced thrombocytopenia and pulmonary embolism. Review of the previously described cases of heparin-associated skin necrosis reveals that this sequence of events is not uncommon.