Maintenance of skeletal muscle mass is regulated by the balance between anabolic and catabolic processes. Mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase, and is known to play vital roles in protein synthesis. Recent findings have continued to refine our understanding of the function of mTOR in maintaining skeletal muscle mass. mTOR controls the anabo...

[Purpose] To clarify t he relationship between the level of independence in activities daily living (ADL) and Skeletal Muscle Mass Index (SMI), as well prevalence low skeletal muscle mass, care-dependent elderly residents nursing homes. [Participants Methods] In 39 women special homes, Barthel (BI) representing ADL mass based on bioelectrical impedance analysis to calculate SMI were measured, c...

introduction: satellite cells are known as the main regenerative cell type in skeletal muscles. our study established a modified digestion and preplating method for the isolation of slow or weak adherent cells for the enrichment of satellite cells. low-survival rate of these primary stem cells prompted us to address whether cell culture medium substitution might change cell viability status. me...

background: the purpose of present study was to investigate whether sphingosine 1-phosphate (s1p) levels and its receptors gene expressions are correlated with myod and myogenin following resistance training. materials and methods: 24 eight-week-old male wistar rats (190-250 gr) were assigned randomly to a control (n = 12) or training (n = 12) group. rats climbed a resistance training ladder wi...

Skeletal muscle is a vital tissue not only for maintaining posture and body movements but also energy metabolism in human body. highly plastic response to various stimuli, resistance exercise or anabolic hormones can increase mass, which termed “muscle hypertrophy”. Contrary, immobility, aging severe illness reduce atrophy”. Loss of skeletal mass associated with loss independent living, the mor...

BACKGROUND Aging is associated with physical inactivity, low energy intake, and loss of skeletal muscle mass. It is not clear whether regular physical activity and adequate dietary protein intake can attenuate the loss of skeletal muscle mass. OBJECTIVE We hypothesized that the maintenance of physical activity and dietary protein intake would attenuate the age-related decline in total appendi...

BACKGROUND Low skeletal muscle mass is associated with poor postoperative outcomes in cancer patients. Furthermore, it is associated with increased healthcare costs in the United States. We investigated its effect on hospital expenditure in a Western-European healthcare system, with universal access. METHODS Skeletal muscle mass (assessed on CT) and costs were obtained for patients who underw...

[Purpose] Handgrip strength is a surrogate indicator for assessing disease-related and age-related skeletal muscle loss. Clinical utility as such a surrogate can be at least partially explained by the close relationship between handgrip strength and whole-body skeletal muscle mass. The handgrip strength is related to hand muscle size. Thus, the present study examined whether hand muscle thickne...

OBJECTIVES 1) To study if limb length explains variability in appendicular and total muscle mass better than height and 2) if muscle mass adjusted for limb length rather than height correlates better with grip and knee extension strength. METHODS 400 healthy women aged 20-40 were recruited as a reference population. Body composition, limb length, grip strength and knee extension strength were...

Skeletal muscle comprises approximately 40% of body weight, and is important for locomotion, as well as for metabolic homeostasis. Adult skeletal muscle mass is maintained by a fine balance between muscle protein synthesis and degradation. In response to cytokines, nutrients, and mechanical stimuli, skeletal muscle mass is increased (hypertrophy), whereas skeletal muscle mass is decreased (atro...