i List of Figures iii List of Table iv

Site-directed mutagenesis is still a very efficient strategy to elaborate improved enzymes. Recently, advances have been made in developing rational strategies aimed at reshaping enzyme specificities and mechanisms, and at engineering biocatalysts through molecular assembling. These knowledge-based studies greatly benefit from the most recent computational analyses of enzyme structures and func...

The present study was intended to identify the effect of a CAI web site for swimming to elementary school children’s learning motives and learning strategy. Fifth-grade children participated in this study. Subjects were classified into two groups that learned with the CAI web site throughout the swimming class and a control group that merely participated in the ordinary swimming class inside th...

Web site usability and accessibility continues to be a pressing problem. Hence, there are over 30 automated evaluation tools to help designers to improve their sites. Unfortunately, there is little evidence about whether these tools actually improve sites from both the designer’s and the user’s perspectives. To gain insight, we conducted what we believe to be the first study of automated web si...

This article reports a content analysis of the privacy policy statements (PPSs) from 97 general reference health Web sites that was conducted to examine the ways in which visitors' privacy is constructed by health organizations. PPSs are formal documents created by the Web site owner to describe how information regarding site visitors and their behavior is collected and used. The results show t...

Mammalian expression systems, due to their capacity in post-translational modification, are preferred systems for biopharmaceutical protein production. Several recombinant protein systems have been introduced to the market, most of which are under clinical development. In spite of significant improvements such as cell line engineering, introducing novel expression methods, gene silencing and pr...