Hepatic sinusoidal obstruction syndrome is commonly described in pediatric oncology as a complication of chemotherapy. It has also been occasionally reported in adult cancer patients. Treatment is largely supportive with fluid restriction. A 16-month-old girl with stage II Wilms tumor receiving post-nephrectomy chemotherapy with dactinomycin and vincristine developed hepatic sinusoidal obstruct...

Hepatic venous outflow obstruction (HVOO) is common in developing countries. It is a serious condition that clinically manifests with ascites from sinusoidal hypertension, and carries the risk of high mortality or development of liver cirrhosis. In the past, the eponym Budd–Chiari Syndrome (BCS) was used synonymously for HVOO. In theWest, hepatic vein (HV) thrombosis caused by prothrombotic dis...

Drug-induced liver injury presents with extremely diverse histologic patterns, including necroinflammatory, cholestatic, steatotic and vascular patterns. Sinusoidal obstruction syndrome (SOS), also referred to as toxic sinusoidal injury, veno-occlusive disease or “blue liver syndrome”, is a commonly recognized vascular pattern of drug-induced liver injury, and has been frequently associated wit...

BACKGROUND Sinusoidal obstruction syndrome (SOS), a form of drug-induced liver injury related to oxaliplatin treatment, is associated with postoperative morbidity after hepatectomy. This study aimed to examine the impact of regorafenib, the first small-molecule kinase inhibitor to show efficacy against metastatic colorectal cancer, on a rat model of SOS. METHODS Rats with monocrotaline (MCT)-...

(1) Duplicates amon (2) Duplicate public journals; Editor: Giovanni Tarantino. Received: April 5, 2015; revised: May 4, 2015; accepted: May 6, 2015. From the Department of Gastroenterology, General, Hospital of Shenyang Military Area (XW, XQ, XG); and Postgraduate College, Liaoning University of Traditional Chinese Medicine (XW), Shenyang, China. Correspondence: Prof Xiaozhong Guo, MD, PhD, and...