Abstract A simple and sensitive liquid chromatography-mass spectrometric (LC-MS) method has been developed validated for the simultaneous determination of ezetimibe (EZE), atorvastatin calcium (ATO), simvastatin (SMV) in combined dosage forms human plasma. Successful separation studied drugs was achieved on a Zorbax Eclipse Plus C18 column (3.0 × 150 mm, 5 µm) using mobile phase consisting acet...

Nonalcoholic steatohepatitis (NASH), especially as part of the metabolic syndrome (MS), is an increasing burden in Western countries. Statins are already used in MS and seem to be beneficial in liver diseases. The aim of this study was to investigate the molecular mechanisms underlying pleiotropic effects on small GTPases of statins in NASH. NASH within MS was induced in 12-wk-old apoE-/- mice ...

Inkjet–printing technology was used to apply biodegradable and biocompatible polymeric coatings of poly(D, L lactide) with the antiproliferative drugs simvastatin (SMV) and paclitaxel (PCX) on coronary metal stents. A piezoelectric dispenser applied coating patterns of very fine droplets (300 xL) and ink jetting was optimized to develop uniform, accurate and reproducible coatings of high yields...

Simvastatin is a hypolipidemic drug used with exercise, diet and weight – loss to control elevated cholesterol or hypercholesterolemia. It is a member of the Statin class of pharmaceuticals. This paper delives voltammetric techniques is an electrochemical technique used in analytical applications and fundamental studies of electrode mechanism. This review summarizes some of the recent developme...

ABSTRACT Transgenic soybean (Glycine max) plants expressing Soybean mosaic virus (SMV) helper component-protease (HC-Pro) showed altered vegetative and reproductive phenotypes and responses to SMV infection. When inoculated with SMV, transgenic plants expressing the lowest level of HC-Pro mRNA and those transformed with the vector alone initially showed mild SMV symptoms. Plants that accumulate...

New achievements in the field of communication technology enabled an innovative approach solving existing problems power system. The IEC 61850 norm provides a standardized among secondary equipment devices. Numerical relays have limited internal memory terms data storage and capability subsequent analysis. Therefore feasibility making high resolution long term records using open-source hardware...

Plants of Senna occidentalis (sin. Cassia occidentalis) with mosaic symptoms were collected near a soybean (Glycine max) field where some plants exhibited symptoms of mosaic and blistering. A preliminary examination of leaf tissue from diseased S. occidentalis by electron microscopy revealed the presence of pinwheel inclusions as well as long flexuous particles, indicating the presence of a pot...

Soybean mosaic virus (SMV; Genus Potyvirus; Family Potyviridae), one of the most widespread viruses in soybean (Glycine max [L.] Merr), can be effectively managed by deployment of resistance. Hutcheson, one SMV-resistant cultivar, is widely used in the MidSouth region and carries an Rsv1 allele for resistance to SMV pathotypes G1-G3, the common strains in US soybean fields. Recently, resistance...

soybean mosaic virus (smv) which belongs to the virus family potyviridae, causes a disease in soybean that is present in soybean-growing areas of the world, and is widely distributed in northern iran. detection of smv is very important for disease management. in the present study several serological and molecular (nucleic acid- based) methods of rapid virus detection were compared. serological ...