direct orthogonal signal correction(dosc) and savitzky-golay filters (sgf) were applied as preprocessing methods on the original and first derivative absorbance data. principle component regression (pcr), partial least squares (pls) and iterative target transformation factor analysis (ittfa), were used in spectrophotometric simultaneous determination of heavy divalent metal ions, lead, zinc,mer...

paracetamol that is known as acetaminophen have the most consume as an analgesic and antipyreticdrug in the world. that is formulated in single compound or mixture at many forms such astablets, syrups, suspensions and drops. the last form is intravenous injections. paracetamol derivedfrom 4-minophenol which is synthesized by acylated the p-acetaminophenol and acetic anhydride.4-aminophenol is t...

In this study, incorporation of iron ion-doped natrolite nanozeolite, multi-wall carbon nanotubes into chitosan-coated glassy carbon electrode for the simultaneous determination of ascorbic acid, epinephrine, uric acid and tyrosine is studied. The results show that the combination of multi-wall carbon nanotubes and iron ion-doped natrolite zeolite causes a dramatic enhancement in the sensitivit...

A method fbr high-perfbrmance liquid chromatography (HPLC) has been estahlished fbr the simultaneous determination of rheinanthrone, sennidin A, scnnidin B and rhein formed by incubation f sennoside A with rat and mouse feces. The analysis was done within 20 min with a Wakosil-II5C18HG column by linear gradient elution using a mobile phase containing aqucous phosphoric acid and acetonitrile. Rh...

combination dosage forms of naproxen sodium and pseudoephedrine hydrochloride are used for symptomatic treatment of cold and sinus disorders. in this study, fourth-order derivative spectrophotometric method was used for simultaneous determination of naproxen sodium and pseudoephedrine hydrochloride. the method was linear over the range of 2-28 μg/ml for pseudoephedrine hydrochloride and 4-200 μ...

A simple, accurate and precise HPTLC- densitometry method for the simultaneousdetermination of abacavir, lamivudine and zidovudine in pharmaceutical tablet has beendeveloped. Separation of tablet components was performed on aluminum backed HPTLC plates(silica gel 60 F254 20×20 cm with 0.2 mm thickness, Camag, Muttenz, Switzerland ) usingmethanol : chloroform : acetonitrile (4 : 8 : 3 v/v). Good...

Three antituberculosis medications are investigated in this work consist of rifampicin, isoniazid and pyrazinamide. The ultra violet (UV) spectra of these compounds are overlapped, thus use of suitable chemometric methods are helpful for simultaneous spectrophotometric determination of them. A generalized version of net analyte signal standard addition method (GNASSAM) was used for determinatio...

A simple, sensitive and highly selective electrochemical method was developed for the simultaneous determination of nitazoxanide and ofloxacin in aqueous media (Britton-Robinson buffer, pH-8.36) on a hanging mercury drop electrode (HMDE) using differential pulse polarography (DPP). Using DPP a separation of about 936 mV between the peak oxidation potentials of nitazoxanide and ofloxacin present...

The H-point standard addition method (HPSAM) was applied to the simultaneous determination of Bi(III) and Sb(III). This method is based on the difference in the absorbance of complexes of Bi(III) and Sb(III) with iodide in acidic media in different wavelength pairs. The results showed that Bi(III) and Sb(III) can be determined simultaneously with concentration ratios of 15:1 to 1:20. First-deri...