Ionic liquids (ILs) have been exploited to improve the absorption of poorly water-soluble drugs. Custom-made ILs solubilized very high quantities of the poorly water-soluble drugs, danazol and itraconazole, and maintained drug solubilization under simulated gastro-intestinal conditions. A danazol-containing self-emulsifying IL formulation gave rise to 4.3-fold higher exposure than the crystalli...

The aim of this work was to produce synbiotic apple juice and investigate the survival of Lactobacillus acidophilus and Lactobacillus plantarum in apple juice during the refrigerated storage (4 °C) for 42 days and then the ability of the mentioned probiotic bacteria in gastrointestinal tolerance under gastrointestinal tract conditions, with simulated gastric and bile juices. Eight-...

The present article describes the second part of a study investigating the effect of adding vegetables on the nutritional, physico-chemical, and oxidative properties of wheat bread, and specifically focuses on bread that does not contain oil as an added ingredient. Wheat flour breads fortified with freeze-dried carrot, tomato, beetroot or broccoli were developed and assessed for their nutrition...

The Milky Way stellar halo contains relics of ancient mergers that tell the story our Galaxy's formation. Some them are identified due to their similarity in energy, actions and chemistry, referred as "chemodynamical space", often attributed distinct merger events. It is also known Galaxy went through a significant event shaped local during its first Gyr. Previous studies using $N$-body only co...

objective:the purpose of this study was to investigate the effects of piroxicam co-administration with ethanolic stem-bark extract of khaya senegalensis on biomarkers of oxidative stress and gastro-toxicity in wistar rats. materials and methods: thirty healthy male and female albino wistar rats (190-220 g) were grouped into six (n = 5) with designated treatments including: normal saline, piroxi...