Time-of-flight secondary ion mass spectrometry (TOF-SIMS) emerges as a promising tool to identify the ions (small molecules) indicative of disease states from the surface of patient tissues. In TOF-SIMS analysis, an enhanced ionization of surface molecules is critical to increase the number of detected ions. Several methods have been developed to enhance ionization capability. However, how thes...

Objective: We developed a simple non-invasive I-123-N-isopropyl-p-iodoamphetamine (123I-IMP) quantification method by analyzing chest RI-angiography and single photon emission computed tomography (SPECT) images based on the microsphere model (SIMS method). Theoretically, the SIMS method could be changed to the simple non-invasive ARG (SIARG) method by modifying the integrated washout ratio (WR)...

The current implementation of situation interpretation metrics (SIMs) in context-based reasoning (CxBR) simulations makes it difficult to effectively and efficiently characterize situations in the simulation. While previous work in the field has dealt to a certain extent with SIMs, the primary focus of such work has been in other areas. Thus, while the current implementation of SIMs is function...

The purpose of this study was to examine the effects of (a) skill test type, (b) choices, and (c) gender on the situational motivation profiles of adolescents during skill testing in physical education. Participants were 507 students (53% male) aged 12–16 years (M = 13.87; SD = 0.94) attending a suburban junior high school in a western state in the U.S. All participants experienced either a nor...

Damage introduced by dynamic secondary ion mass spectrometry ~SIMS! depth profiling is studied. A silicon sample with a boron marker layer was depth profiled by dynamic SIMS. After subsequent annealing at 750 °C for 30 min, the SIMS sample was reanalyzed by plan-view transmission electron microscope ~PTEM! and SIMS. PTEM images showed the presence of interstitial defects near the original SIMS ...

In this study we present an initial dataset of Mn/Ca and Fe/Ca ratios in tests of benthic foraminifera from the Peruvian oxygen minimum zone (OMZ) determined with SIMS. These results are a contribution to a better understanding of the proxy potential of these elemental ratios for ambient redox conditions. Foraminiferal tests are often contaminated by diagenetic coatings, like Mn rich carbonateo...

This article is a concise review of the application of secondary ion mass spectrometry (SIMS) to the imaging of biological cells. The paper covers the various advantages and disadvantages of different approaches to SIMS analysis with respect to the information that can be gained from the interrogation of the cells. Current successes, pitfalls and future potential for SIMS in cell imaging are di...

Many service identification methods (SIMs) have been proposed to support the determination of services that are appropriate for use in an SOA. However, these SIMs vary in terms of analysis objectives, identification procedures and service hierarchies. Due to the heterogeneity of the SIMs, practitioners often face the difficulty of choosing a SIM that copes with available resources and fits thei...

The purpose of the present research was to develop and validate a situational (or state) measure of motivation, the Situational Motivation Scale (SIMS). The SIMS is designed to assess the constructs of intrinsic motivation, identified regulation, external regulation, and amotivation (E. L. Deci & R. M. Ryan, 1985, 1991) in field and laboratory settings. Five studies were conducted to develop an...

We tested the suitability of two spectroscopic methods, x-ray photoelectron spectroscopy (XPS) and time of flight secondary ion mass spectrometry (ToF-SIMS), in the recognition of bacterial and eukaryotic cell footprints on implant surfaces. Human mesenchymal stem cells (MSCs) and Staphylococcus aureus were cultured on sample surfaces and detached using trypsin. Scanning electron microscopy con...