intracranial aspergilloma is extremely rare. the diagnosis and treatment of invasive cns aspergillosis is very difficult. early diagnosis is important for a successful treatment. here, we report a case of intracranial aspergilloma in an 11-year-old boy in 2013. good outcome was achieved by treatment with a combination of neurosurgical resection and antifungal administration, which we suggest is...

noncoding ribonucleic acids micro-rna is involved in the regulation of gene expression have major roles in the post-transcriptional level. a micro-rna alone several causes down regulation of mrna transcript of the target. thus, small changes in the expression of a micro rna may lead to significant changes in gene expression are different. micro- rna as key regulators of immune cell lineage diff...

primary angiitis of the central nervous system (pacns) is an idiopathic disorder (vasculitis) restricted to the central nervous system (cns). it often presents with focal neurological deficits suggesting stroke or a combination of confusion and headache. we herein report three cases with various combinations of fever, partial seizure, encephalopathy, paresis, headache and ataxia. one of them wa...

objective primary central nervous system lymphoma (pcnsl) is an extremely rare condition in childhood. we report the first case of pcnsl in a child in iran. clinical presentation a nine-year-old boy was referred to mofid hospital with the history of headache of four months and seizure of 2 months duration. magnetic resonance imaging of the brain revealed a hyper-intense lesion in left fronto-pa...

microglia is a type of glial cell located throughout the central nervous system (cns), which is sensitive to cns injury and disease. responsibility of microglia as the resident macrophage cells for injuries suggests that these cells have the potential to act as diagnostic markers of disease beginning or progression. function of microglia is strongly synchronized by the microenvironment of brain...

in this study, a 2.5-year-old boy suffering from a febrile seizure with normal laboratory tests and a history of immune hemolytic anemia was examined. brain mri demonstrated some tumors in the frontal, parietal, and occipital lobe that corroborated the pathology results of primary central nervous system lymphoma for the patient. the patient was treated with high- dose of methotrexate. our resul...

Silver syndrome (Silver spastic paraplegia syndrome) is a rare disorder of the peripheral nervous system that combines features of spastic paraparesis and peripheral neuropathy. The underlying genetic defects are two mutations in the BSCL2 gene which have been described in several families. Silver syndrome--related to the N88S mutation in the BSCL2 gene--is characterized by a spectrum of clinic...

amitraz is a triazapentadiene, an α2 adrenergic agonist and a member of the amidine chemical family. a limited number of human intoxication cases have been published in the literature. lack of a clear and specific protocol for the therapy of amitraz intoxication may make its successfully managed case reports useful and valuable for other clinical practitioners in poisoning departments. the case...

fructose consumption has increased dramatically in the last 40 years, and its role in the pathogenesis of the metabolic syndrome has been implicated by many studies. it is most often encountered in the diet as sucrose (glucose and fructose) or high-fructose corn syrup (55% fructose). at high levels, dietary exposure to fructose triggers a series of metabolic changes originating in the liver, le...