Sigma-1 receptor (Sig-1R) functions as a chaperon that interacts with multiple proteins and lipids and is implicated in neurodegenerative and psychiatric diseases. Here, we used Sig-1R KO mice to examine brain expression profiles of astrocytes and ubiquitinated proteins, which are both hallmarks of central nervous system (CNS) pathologies. Our results showed that Sig-1R KO induces increased gli...

This paper addresses the question of how to increase local coherence in summaries of multi-party conversations. Due to the interactive nature of dialogues, local regions of coherence often stretch across diierent speakers, as for instance in question-answer pairs. We present an approach to automatically detect those regions of local coherence and evaluate the resulting summaries' uency and info...

This paper presents a parameterized version of the stochastic information gradient (SIG) algorithm, in which the error distribution is modeled by generalized Gaussian density (GGD), with location, shape, and dispersion parameters. Compared with the kernel-based SIG (SIGKernel) algorithm, the GGD-based SIG (SIG-GGD) algorithm does not involve kernel width selection. If the error is zero-mean, th...

In the brain, myelin is important in regulating nerve conduction and neurotransmitter release by providing insulation at axons. Myelin is a specialized yet continuous sheet structure of differentiated oligodendrocytes (OLs) that is enriched in lipids, specifically galactosylceramides (GalCer) originated at the endoplasmic reticulum (ER). GalCer are known to affect OL differentiation. However, t...

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With the increasing application requirements of spatial information, traditional spatial information techniques can not solve current application problems. As novel technologies that can implement sharing of enormous distributed resource, Grid and Web services provide an effective and efficient way to share and integrate spatial information on the web. Hence, an innovate framework, i.e. Spatial...

The endoplasmic reticulum (ER) chaperone σ-1 receptor (Sig-1R) is cytoprotective against ER stress-induced apoptosis. The level of Sig-1Rs in the brain was reported to be lower in early parkinsonian patients. Because dopamine (DA) toxicity is well known to be involved in the etiology of Parkinson's disease, we tested in this study whether a relationship might exist between Sig-1Rs and DA-induce...

Neurite outgrowth is one of the essential processes underlying development and plasticity of the nervous system. Enhancing neurite outgrowth, along with neural protection, is one of the most prominent therapeutic strategies against neuronal degeneration or damage. The sigma-1 receptor (Sig-1R) is a brain-enriched a receptor chaperone expressed in the ER membrane. As Sig-1R is involved in the mo...

Dysregulation of cyclin-dependent kinase 5 (cdk5) per relative concentrations of its activators p35 and p25 is implicated in neurodegenerative diseases. P35 has a short t½ and undergoes rapid proteasomal degradation in its membrane-bound myristoylated form. P35 is converted by calpain to p25, which, along with an extended t½, promotes aberrant activation of cdk5 and causes abnormal hyperphospho...