Regulators such as the U.S. Food and Drug Administration have elaborate, multi-year processes for approving new drugs as safe and effective. Nonetheless, in recent years, several approved drugs have been withdrawn from the market because of serious and sometimes fatal side effects. We describe statistical methods for post-approval data analysis that attempt to detect drug safety problems as qui...

editorial

background: hemoglobin s arises is the result of a point mutation (a-t) in the sixth codon on the -globin gene on chromosome 11 causing sickle cell anemia. the presence of fetal hemoglobin in infancy plays a relatively protective role for vaso-occlusive symptoms that are the major contributor for the morbidity and mortality among patients with sickle cell anemia. hydroxyurea, an s-phase-specif...

We follow a research thread studying the predecessor problem on “smooth” distribution families. We propose a conceptually simpler solution utilizing wellknown results from much better studied variant of the problem that assumes nothing about the input. As a side effect, we are able to extend the range of handled input distributions for the most studied case needing expected O (log log n) time, ...

In this paper the known upper bound 10 for the number of Diophantine quintuples is reduced to 6.8·10. The key ingredient for the improvement is that certain individual bounds on parameters are now combined with a more efficient counting of tuples, and estimated by sums over divisor functions. As a side effect, we also improve the known upper bound 4 ·10 for the number of D(−1)-quadruples to 5 ·...

human serum albumin (hsa) is an abundant, multifunctional and nonglycosylated negatively charged plasma protein. hsa ascribed ligand-binding and transport properties, antioxidant functions and enzymatic activities. in the present study, the interaction and side effects of a new designed anti-cancer compound (1,10-phenanthroline butyl dithiocarbamato palladium(ii) nitrate) on hsa have been inves...

introduction: today, lasik surgery is one of the most common and effective procedures for correction of refractive errors. less than 1% of patients undergoing lasik operation suffer from serious and 3-5% suffers from mild complications. also, results of lasik in most centers are promising. with the recent inauguration of the lasik center of yazd, it was decided to evaluate the results and compl...

Using a household survey and regression methods, we assessed preferences for prescribed fire in the southern United States. We found that the majority of the respondents favored the use of prescribed fire. However, we observed pronounced racial variation in opinions on prescribed fire and its side effects. African Americans and Hispanics were less supportive and were more concerned about the si...

As a popular drug, suramin has attracted much attention for a century. It has an extensive record of clinical trials. This review article gives a brief introduction of its wide biological roles, remarkable pharmacological activities, and several side effects. Chemists and biological scientists have been working together for the design and synthesis of its derivatives and analogues. Some structu...

background: radiation therapy is an effective method used for treatment of many types of cancers. however, this method can cause unwanted side effects such as bone marrow suppression. in this study, the effect of oral administration of biogenic selenium nanoparticles (senps) on total and differentiated white cells profile of balb/c mice exposed to x-ray radiation was investigated and compared w...