The mechanisms of respiratory action of the intercostal muscles were studied by measuring the effect of external forces (F) applied to the ribs and by modeling the effect of F exerted by the intercostal muscles. In five dogs, with the airway occluded, cranial F were applied to individual rib pairs, from the 2nd to the 11th rib pair, and the change in airway opening pressure (Pao) was measured. ...

BACKGROUND Osteogenesis imperfecta (OI) is an inherited connective tissue disorder characterized by bone fragility, multiple fractures and significant chest wall deformities. Cardiopulmonary insufficiency is the leading cause of death in these patients. METHODS Seven patients with severe OI type III, 15 with moderate OI type IV and 26 healthy subjects were studied. In addition to standard spi...

Shifting the location of a dielectric boundary in the cross section of an integrated optical waveguide with piecewise constant refractive index profile results in a permittivity perturbation in a layer along the discontinuity line. On the basis of these thin layer perturbations, we discuss perturbational expressions for the derivatives of the propagation constants with respect to geometry param...

In this work, detailed design and realization of high quality factor (Q) racetrack resonators based on silicon-on-insulator rib waveguides are presented. Aiming to achieve critical coupling, suitable waveguide geometry is determined after extensive numerical studies of bending loss. The final design is obtained after coupling factor calculations and estimation of propagation loss. Resonators wi...

Vaso-occlusive crises cause most of the morbidity and mortality associated with sickle cell disease. The proximal causes of these occlusive events are not well understood. The risks and consequences of vaso-occlusion however are clear. Ten percent of sickle cell disease patients will have a stroke by the age of 20. Two thirds of sickle cell disease patients require more than one hospitalization...

Abstract Background Prevalence of hereditary blood diseases such as sickle cell anemia, sickle thalassemia and thalassemia major are high in Khuzestan province. Sickle cell anemia and beta-thalassemia are predominantly common in Iranian Arabs. Pulmonary complications account for a large proportion of morbidity and mortality in patients with and sickle cell disease. Periodic lung function asse...

The present work is carried out to investigate heat transfer and friction factor characteristics of fluid (air) flow through turbulent channel i.e. parallel plate heat exchanger for different geometry and designs parameters, with a bottom plate applied to uniform constant heat flux thermal boundary condition, and upper plate is provided with a insulated condition. The fluid domain is designed u...

abstract background prevalence of hereditary blood diseases such as sickle cell anemia, sickle thalassemia and thalassemia major are high in khuzestan province. sickle cell anemia and beta-thalassemia are predominantly common in iranian arabs. pulmonary complications account for a large proportion of morbidity and mortality in patients with and sickle cell disease. periodic lung function assess...

Various models of the human chest have been developed to evaluate injury risks or to assess innovative safety systems. In the frame of the EU FP7 project THOMO, a protocol has been established to determine relevant parameters of the human ribcage. This original method has been developed by combining CT-scan, 3D laser scan and μCT-scan to determine precisely the internal rib architecture. The ma...