BACKGROUND Cardiovascular system abnormalities are common causes of morbidity and mortality in sickle cell anaemia. OBJECTIVES The study aims at determining the pattern of electrocardiographic changes in adult Nigerian sickle cell anaemia patients. METHODS A descriptive cross sectional study was done on sixty sickle cell anaemia patients seen at the adult sickle cell clinic of University of...

1. Glomerular filtration rate and effective renal blood-flow were normal in a series of patients with sickle cell anaemia. Fractional creatinine excretion and fractional urea excretion were increased. 2. During indomethacin administration there were significant falls in glomerular filtration rate, effective renal blood-flow, creatinine clearance and urea clearance in the patients with sickle ce...

BACKGROUND Trace elements are required for the performance of numerous functions of immune cells. It is not clear whether levels of trace elements are elevated and whether there is a relationship between the levels of liver enzymes and trace elements in patients with sickle cell anaemia in crisis. OBJECTIVE To compare the plasma levels of liver enzymes and trace elements in non sickle cell an...

Pulmonary hypertension is an emerging complication of sickle cell anaemia with associated increased risk of mortality. In order to evaluate the clinical and electrocardiographic findings in adult sickle-cell patients with pulmonary hypertension, a cross sectional study was conducted on sixty two sickle cell anaemia patients and sixty two age and sex matched normal controls. Elevated pulmonary a...

We report a 20-year-old female with sickle cell anaemia and with an HbF concentration of 15.8%. The patient was not using hydroxyurea and was not receiving regular blood transfusions. The patient never had chronic manifestations of sickle cell anaemia, only pain crises of a mild intensity. After laboratory tests, we found that she was homozygous for HbS with the Bantu/atypical haplotype, and wa...

heterozygous and homozygous states to explain the symptomless sickle cell trait and the true sickle cell anaemia. An individual receiving the haemoglobin S gene from one parent only (the heterozygous state A/S) would have the sickle cell trait, whereas if the gene should be received from both parents (the homozygous state 5/5) he would have sickle cell anaemia (Fig. I). Sickle cell anaemia and ...

Sickle cell anaemia coexisting with gout is a rare clinical association, as is gout and eosinophilia. This report records the second case of chronic tophaceous deposits in Sickle cell anaemia. The patient also had eosinophilia in association with gout. Skeletal fluorosis was an incidental finding in this patient. Treatment with packed cell transfusions, hydroxyurea and colchicine lead to the re...

The genetic control of sickle cell anaemia through prenatal diagnosis has been practiced in many developed nations of the world for many years. This seems not to be common in Nigeria. This stuffy therefore, tried to find out the factors militating against the acceptability of prenatal diagnosis of sickle cell anaemia among health workers in selected hospitals in Anambra State. To achieve this, ...

Patients with sickle cell anaemia have an increased susceptibility to bacterial infections Previous reports of false-negative nitro blue tetrazolium (NBT) tests in the presence of bacteria infection and of a faulty phagocytic response following stimulation in vitro have suggested the possibility of polymorphonuclear dysfunction in certain patients with sickle cell anaemia. In the present study ...